You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SUMO2
Small ubiquitin-related modifier 2

Protein Summary
Description
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314523
  • ENSP00000400886
  • ENSG00000188612
  • ENST00000420826
  • ENSP00000405965

Symbol
  • SMT3B
  • SMT3H2
  • HSMT3
  • SMT3B
  • SUMO3
  • Smt3A
  • SMT3H2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
hub protein
0.98
disease perturbation
0.95
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.04   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 958   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.04   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 958   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
6
1
1
0
1.1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
6
0
1.1
2.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small ubiquitin-like modifier 2
VGNC:51740
454875
Mouse
MGI:2158813
170930
Mouse
MGI:1336201
20610
Rat
RGD:621761
690244
Rat
RGD:1561022
499417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small ubiquitin-like modifier 2
Mouse
Mouse
Rat
Rat
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (360)
1 – 10 of 360
SUMO3
Tbio
Novelty: 0.03096465
p_int: 0.999212138
p_ni: 0.000787862
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
p_int: 0.994896147
p_ni: 0.005103853
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SENP1
Tchem
Family: Enzyme
Novelty: 0.00831213
Score: 0.999
Data Source: Reactome,STRINGDB
SAE1
Tbio
Novelty: 0.01613881
Score: 0.999
Data Source: Reactome,STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
Score: 0.998
Data Source: Reactome,STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.00917672
Score: 0.997
Data Source: STRINGDB
UBA2
Tbio
Novelty: 0.01582807
Score: 0.995
Data Source: Reactome,STRINGDB
SENP2
Tbio
Family: Enzyme
Novelty: 0.17238834
Score: 0.995
Data Source: Reactome,STRINGDB
RNF4
Tbio
Family: Enzyme
Novelty: 0.0119054
Score: 0.994
Data Source: STRINGDB
TDG
Tbio
Family: Enzyme
Novelty: 0.00283178
Score: 0.993
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  291.04

PubMed score by year
PubTator Score  220.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: