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Tbio
RPL37
60S ribosomal protein L37

Protein Summary
Description
Binds to the 23S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274242
  • ENSP00000274242
  • ENSG00000145592

Symbol
  • L37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
disease perturbation
0.96
transcription factor binding site profile
0.94
cell type or tissue
0.78
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.3
92.2
mean corpuscular hemoglobin concentration
1
1
1
54.4
1
1
0
1.2
52
reticulocyte measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
92.2
mean corpuscular hemoglobin concentration
1
54.4
0
1.2
52
reticulocyte measurement
1
47.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L37
695667
Mouse
MGI:1914531
67281
Dog
60S ribosomal protein L37 [Source:RefSeq peptide;Acc:NP_001239158]
Horse
ribosomal protein L37
100066211
Cow
ribosomal protein L37
768317
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L37
Mouse
Dog
60S ribosomal protein L37 [Source:RefSeq peptide;Acc:NP_001239158]
Horse
ribosomal protein L37
Cow
ribosomal protein L37
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61927-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (395)
1 – 10 of 395
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.99994705
p_ni:  0.00005295
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999932817
p_ni:  0.000067183
Data Source:  BioPlex
MRPL51
Tdark
Novelty:  0.24304433
p_int:  0.999621037
p_ni:  0.000378961
p_wrong:  2e-9
Data Source:  BioPlex
MRPL40
Tbio
Novelty:  0.09916967
p_int:  0.999404238
p_ni:  0.000595762
Data Source:  BioPlex
MRPL55
Tdark
Novelty:  0.55956177
p_int:  0.999323421
p_ni:  0.000676579
Data Source:  BioPlex
MRPL45
Tdark
Novelty:  0.42464896
p_int:  0.999234753
p_ni:  0.000765247
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999104556
p_ni:  0.000874823
p_wrong:  0.000020621
Data Source:  BioPlex
IPO5
Tbio
Novelty:  0.00452607
p_int:  0.999002842
p_ni:  0.000997158
Data Source:  BioPlex
MRPL16
Tdark
Novelty:  0.38562971
p_int:  0.998386255
p_ni:  0.001613745
Score:  0.354
Data Source:  BioPlex,STRINGDB
MRPL28
Tdark
Novelty:  0.23845162
p_int:  0.998087757
p_ni:  0.001912243
Data Source:  BioPlex
Publication Statistics
PubMed Score  23.05

PubMed score by year
PubTator Score  19.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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