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Tbio
NPC2
NPC intracellular cholesterol transporter 2

Protein Summary
Description
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). This gene encodes a protein containing a lipid recognition domain. The ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000541064
  • ENSP00000442488
  • ENSG00000119655
  • ENST00000555619
  • ENSP00000451112

Symbol
  • HE1
  • HE1
  • EDDM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
transcription factor perturbation
0.94
virus perturbation
0.92
histone modification site profile
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.02   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.02   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
p_int:  0.999915187
p_ni:  0.000084813
Score:  0.189
Data Source:  BioPlex,STRINGDB
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.99908358
p_ni:  0.00091642
Data Source:  BioPlex
CFB
Tchem
Novelty:  0.00102672
p_int:  0.998895642
p_ni:  0.000940978
p_wrong:  0.00016338
Score:  0.697
Data Source:  BioPlex,STRINGDB
TTR
Tclin
Novelty:  0.0001199
p_int:  0.997050137
p_ni:  0.002949734
p_wrong:  1.29e-7
Score:  0.921
Data Source:  BioPlex,STRINGDB
PIEZO1
Tchem
Family:  IC
Novelty:  0.00374633
p_int:  0.98199341
p_ni:  0.01800659
Data Source:  BioPlex
RRAGA
Tbio
Novelty:  0.02022668
p_int:  0.977226785
p_ni:  0.022734452
p_wrong:  0.000038764
Score:  0.249
Data Source:  BioPlex,STRINGDB
CD160
Tbio
Novelty:  0.01511748
p_int:  0.957366834
p_ni:  0.042632956
p_wrong:  2.1e-7
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.952529959
p_ni:  0.047470041
Data Source:  BioPlex
IRGQ
Tdark
Family:  Enzyme
Novelty:  0.9065415
p_int:  0.935416197
p_ni:  0.026274197
p_wrong:  0.038309606
Score:  0.187
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.934048552
p_ni:  0.065951448
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
LDL clearance
Reactome
Neutrophil degranulation
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
LDL clearance
Neutrophil degranulation
Plasma lipoprotein assembly, remodeling, and clearance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
4
5
89.4
self reported educational attainment
1
1
1
64.4
intraocular pressure measurement
3
3
3
63.6
mathematical ability
2
2
2
60.1
BMI-adjusted waist circumference
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
89.4
self reported educational attainment
1
64.4
intraocular pressure measurement
3
63.6
mathematical ability
2
60.1
BMI-adjusted waist circumference
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPC intracellular cholesterol transporter 2
VGNC:10310
450192
Macaque
NPC intracellular cholesterol transporter 2
699881
Mouse
MGI:1915213
67963
Rat
RGD:628756
286898
Dog
NPC intracellular cholesterol transporter 2
VGNC:43914
403920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPC intracellular cholesterol transporter 2
Macaque
NPC intracellular cholesterol transporter 2
Mouse
Rat
Dog
NPC intracellular cholesterol transporter 2
Publication Statistics
PubMed Score 283.02
PubMed score by year
PubTator Score 205.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title