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Tbio
TGFB2
Transforming growth factor beta-2 proprotein

Protein Summary
Description
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity). Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366929
  • ENSP00000355896
  • ENSG00000092969
  • ENST00000366930
  • ENSP00000355897

Symbol
  • LDS4
  • G-TSF
  • TGF-beta2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
biological term
0.96
gene perturbation
0.96
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2023.39   (req: < 5)
Gene RIFs: 207   (req: <= 3)
Antibodies: 528   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2023.39   (req: >= 5)
Gene RIFs: 207   (req: > 3)
Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
95.1
body height
5
3
6
91.8
heel bone mineral density
2
1
2
75.9
BMI-adjusted waist circumference
5
4
10
67.1
central corneal thickness
2
1
0
2
64.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
95.1
body height
6
91.8
heel bone mineral density
2
75.9
BMI-adjusted waist circumference
10
67.1
central corneal thickness
0
2
64.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta 2
VGNC:7006
457742
Macaque
transforming growth factor beta 2
707540
Mouse
MGI:98726
21808
Rat
RGD:70491
81809
Dog
transforming growth factor beta 2
VGNC:47309
488596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta 2
Macaque
transforming growth factor beta 2
Mouse
Rat
Dog
transforming growth factor beta 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61812-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Elastic fibre formation
Extracellular matrix organization
Hemostasis
Molecules associated with elastic fibres
Gene Ontology Terms (120)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (194)
1 – 10 of 194
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
Score: 0.986
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.984
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.976
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.969
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.968
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.963
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.961
Data Source: Reactome,STRINGDB
LTBP3
Tbio
Novelty: 0.0190763
Score: 0.957
Data Source: Reactome,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.956
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  2023.39

PubMed score by year
PubTator Score  942.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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