You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
B2M
Beta-2-microglobulin

Protein Summary
Description
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000558401
  • ENSP00000452780
  • ENSG00000166710
  • ENST00000559916
  • ENSP00000453350
  • ENST00000561424
  • ENSP00000453191
  • ENST00000617605
  • ENSP00000481426
  • ENSG00000273686
  • ENST00000631573
  • ENSP00000488548
  • ENST00000631728
  • ENSP00000488321
  • ENST00000648006
  • ENSP00000497910

Symbol
  • IMD43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease perturbation
1
virus perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8021.16   (req: < 5)
Gene RIFs: 262   (req: <= 3)
Antibodies: 2183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8021.16   (req: >= 5)
Gene RIFs: 262   (req: > 3)
Antibodies: 2183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (504)
1 – 10 of 504
RGPD2
Tdark
Novelty:  0.02695062
p_int:  0.999999975
p_ni:  6e-9
p_wrong:  1.9e-8
Score:  0.552
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999999467
p_ni:  5.33e-7
Score:  0.963
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.99999784
p_ni:  0.00000216
Data Source:  BioPlex
DLGAP5
Tbio
Novelty:  0.01673312
p_int:  0.99998432
p_ni:  0.00001566
p_wrong:  2e-8
Score:  0.524
Data Source:  BioPlex,STRINGDB
TPST1
Tbio
Family:  Enzyme
Novelty:  0.03915379
p_int:  0.999839163
p_ni:  0.000122084
p_wrong:  0.000038753
Score:  0.19
Data Source:  BioPlex,STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
p_int:  0.999805914
p_ni:  0.000194086
Score:  0.815
Data Source:  BioPlex,STRINGDB
RANGAP1
Tbio
Family:  Enzyme
Novelty:  0.00917672
p_int:  0.99862759
p_ni:  0.00137241
Score:  0.827
Data Source:  BioPlex,STRINGDB
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.990978394
p_ni:  0.009021497
p_wrong:  1.09e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
KPNA4
Tbio
Novelty:  0.01326511
p_int:  0.981971745
p_ni:  0.018028255
Score:  0.183
Data Source:  BioPlex,STRINGDB
CDCA2
Tbio
Novelty:  0.04666018
p_int:  0.976364702
p_ni:  0.021044365
p_wrong:  0.002590932
Score:  0.183
Data Source:  BioPlex,STRINGDB
Pathways (33)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amyloid fiber formation
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amyloid fiber formation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (59)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
79.5
apolipoprotein A 1 measurement
1
1
1
72.6
sex hormone-binding globulin measurement
4
1
4
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
79.5
apolipoprotein A 1 measurement
1
72.6
sex hormone-binding globulin measurement
4
62.6
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-2-microglobulin
VGNC:11825
450170
Macaque
beta-2-microglobulin
712428
Mouse
MGI:88127
12010
Rat
RGD:2189
24223
Dog
beta-2-microglobulin
VGNC:38331
100855741
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-2-microglobulin
Macaque
beta-2-microglobulin
Mouse
Rat
Dog
beta-2-microglobulin
Publication Statistics
PubMed Score 8021.16
PubMed score by year
PubTator Score 6607.69
PubTator score by year