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Tbio
B2M
Beta-2-microglobulin

Protein Summary
Description
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000558401
  • ENSP00000452780
  • ENSG00000166710
  • ENST00000559916
  • ENSP00000453350
  • ENST00000561424
  • ENSP00000453191
  • ENST00000617605
  • ENSP00000481426
  • ENSG00000273686
  • ENST00000631573
  • ENSP00000488548
  • ENST00000631728
  • ENSP00000488321
  • ENST00000648006
  • ENSP00000497910

Symbol
  • IMD43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease perturbation
1
virus perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8925.37   (req: < 5)
Gene RIFs: 307   (req: <= 3)
Antibodies: 2183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8925.37   (req: >= 5)
Gene RIFs: 307   (req: > 3)
Antibodies: 2183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0