Tbio STXBP1 Syntaxin-binding protein 1

Protein Summary

Description

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P61764
• B1AM97
• Q28208
• Q62759
• Q64320
• Q68CM6
• Q96TG8

Gene Name

• STXBP1

Ensembl ID

• ENST00000373299
• ENSP00000362396
• ENSG00000136854
• ENST00000373302
• ENSP00000362399

Symbol

• UNC18A
• P67
• NSEC1
• UNC18
• RBSEC1
• MUNC18-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
biological process	0.9
hub protein	0.85
kinase	0.85
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Syntaxin-binding Protein 1

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Syntaxin-binding Protein 1

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Syntaxin-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 371.83   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 456   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 371.83   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0