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Tbio
VBP1
Prefoldin subunit 3

Protein Classes
PANTHER Classes Protein / Chaperone / Prefoldin Subunit 3
Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286428
  • ENSP00000286428
  • ENSG00000155959

Symbol
  • PFDN3
  • PFD3
  • PFDN3
  • VBP-1
  • HIBBJ46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
disease perturbation
0.87
kinase perturbation
0.84
histone modification site profile
0.75
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.48   (req: < 5)
View Publications
Gene RIFs: 5   (req: <= 3)
View Gene RIFs
Antibodies: 314   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.48   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
96 targets
R-HSA-390466
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
33 targets
R-HSA-389958
Reactome
Metabolism of proteins
2050 targets
R-HSA-392499
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
28 targets
R-HSA-389957
Reactome
Protein folding
102 targets
R-HSA-391251
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
96 targets
R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
33 targets
R-HSA-389958
Metabolism of proteins
2050 targets
R-HSA-392499
Prefoldin mediated transfer of substrate to CCT/TriC
28 targets
R-HSA-389957
Protein folding
102 targets
R-HSA-391251
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
tubulin binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (168)
1 – 10 of 168
PFDN4
Tbio
Novelty: 0.02826158
p_int: 0.999999118
p_ni: 8.82e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PFDN2
Tbio
Novelty: 0.12469692
p_int: 0.999980947
p_ni: 0.000019053
Score: 0.999
Data Source: BioPlex,STRINGDB
UBL7
Tdark
Novelty: 0.30057803
p_int: 0.999962886
p_ni: 0.000037114
Score: 0.298
Data Source: BioPlex,STRINGDB
PHKB
Tbio
Family: Enzyme
Novelty: 0.06770123
p_int: 0.999937384
p_ni: 0.000062615
Score: 0.229
Data Source: BioPlex,STRINGDB
COPRS
Tbio
Novelty: 0.06881767
p_int: 0.99864069
p_ni: 0.00132067
p_wrong: 0.000038639
Data Source: BioPlex
SGF29
Tbio
Family: Epigenetic
Novelty: 0.00156606
p_int: 0.987097961
p_ni: 0.012902039
Score: 0.179
Data Source: BioPlex,STRINGDB
PFDN5
Tbio
Novelty: 0.09272547
p_int: 0.986330474
p_ni: 0.013669526
Score: 0.999
Data Source: BioPlex,STRINGDB
SUPT6H
Tbio
Novelty: 0.01317094
p_int: 0.984212318
p_ni: 0.01502848
p_wrong: 0.000759202
Score: 0.186
Data Source: BioPlex,STRINGDB
PFDN6
Tbio
Novelty: 0.02635016
p_int: 0.963654549
p_ni: 0.036345451
Score: 0.999
Data Source: BioPlex,STRINGDB
PFDN1
Tbio
Novelty: 0.1113025
p_int: 0.918377222
p_ni: 0.081622778
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.48

PubMed score by year
PubTator Score  10.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer