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Tbio
VBP1
Prefoldin subunit 3

Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286428
  • ENSP00000286428
  • ENSG00000155959

Symbol
  • PFDN3
  • PFD3
  • PFDN3
  • VBP-1
  • HIBBJ46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
disease perturbation
0.87
kinase perturbation
0.84
histone modification site profile
0.75
tissue sample
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999999118
p_ni:  8.82e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.999980947
p_ni:  0.000019053
Score:  0.999
Data Source:  BioPlex,STRINGDB
UBL7
Tdark
Novelty:  0.20935024
p_int:  0.999962886
p_ni:  0.000037114
Score:  0.298
Data Source:  BioPlex,STRINGDB
PHKB
Tbio
Family:  Enzyme
Novelty:  0.05506418
p_int:  0.999937384
p_ni:  0.000062615
Score:  0.229
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.99864069
p_ni:  0.00132067
p_wrong:  0.000038639
Data Source:  BioPlex
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.987097961
p_ni:  0.012902039
Score:  0.179
Data Source:  BioPlex,STRINGDB
PFDN5
Tbio
Novelty:  0.07673574
p_int:  0.986330474
p_ni:  0.013669526
Score:  0.999
Data Source:  BioPlex,STRINGDB
SUPT6H
Tbio
Novelty:  0.01099565
p_int:  0.984212318
p_ni:  0.01502848
p_wrong:  0.000759202
Score:  0.186
Data Source:  BioPlex,STRINGDB
PFDN6
Tbio
Novelty:  0.01632101
p_int:  0.963654549
p_ni:  0.036345451
Score:  0.999
Data Source:  BioPlex,STRINGDB
PFDN1
Tbio
Novelty:  0.08811378
p_int:  0.918377222
p_ni:  0.081622778
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Find Similar Targets
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1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
57.7
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1333804
22327
Dog
VHL binding protein 1
VGNC:48239
481089
Horse
VHL binding protein 1
VGNC:24890
100062203
Cow
VHL binding protein 1
VGNC:36777
508727
Pig
VHL binding protein 1
100514622
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
VHL binding protein 1
Horse
VHL binding protein 1
Cow
VHL binding protein 1
Pig
VHL binding protein 1
Publication Statistics
PubMed Score 22.78
PubMed score by year
PubTator Score 10.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title