Tbio VBP1 Prefoldin subunit 3

Protein Summary

Description

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P61758
• B2R8L5
• O55228
• Q15765
• Q5JT81
• Q86X96

Gene Name

• VBP1

Ensembl ID

• ENST00000286428
• ENSP00000286428
• ENSG00000155959

Symbol

• PFDN3
• PFD3
• PFDN3
• VBP-1
• HIBBJ46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.89
disease perturbation	0.87
kinase perturbation	0.84
histone modification site profile	0.75
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Chaperone / Prefoldin Subunit 3

DTO Classes

Protein / Chaperone / Prefoldin Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (168)

Explore Interacting Targets

1 – 10 of 168

• See Interactions on String-DB

PFDN4

Tbio

Novelty:  0.02133605

p_int:  0.999999118

p_ni:  8.82e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

PFDN2

Tbio

Novelty:  0.08537716

p_int:  0.999980947

p_ni:  0.000019053

Score:  0.999

Data Source:  BioPlex,STRINGDB

UBL7

Tdark

Novelty:  0.20935024

p_int:  0.999962886

p_ni:  0.000037114

Score:  0.298

Data Source:  BioPlex,STRINGDB

PHKB

Tbio

Family:  Enzyme

Novelty:  0.05506418

p_int:  0.999937384

p_ni:  0.000062615

Score:  0.229

Data Source:  BioPlex,STRINGDB

COPRS

Tbio

Novelty:  0.03545787

p_int:  0.99864069

p_ni:  0.00132067

p_wrong:  0.000038639

Data Source:  BioPlex

SGF29

Tbio

Family:  Epigenetic

Novelty:  0.0426456

p_int:  0.987097961

p_ni:  0.012902039

Score:  0.179

Data Source:  BioPlex,STRINGDB

PFDN5

Tbio

Novelty:  0.07673574

p_int:  0.986330474

p_ni:  0.013669526

Score:  0.999

Data Source:  BioPlex,STRINGDB

SUPT6H

Tbio

Novelty:  0.01099565

p_int:  0.984212318

p_ni:  0.01502848

p_wrong:  0.000759202

Score:  0.186

Data Source:  BioPlex,STRINGDB

PFDN6

Tbio

Novelty:  0.01632101

p_int:  0.963654549

p_ni:  0.036345451

Score:  0.999

Data Source:  BioPlex,STRINGDB

PFDN1

Tbio

Novelty:  0.08811378

p_int:  0.918377222

p_ni:  0.081622778

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Chaperonin-mediated protein folding (R-HSA-390466)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Prefoldin mediated transfer of substrate to CCT/TriC	28 targets	R-HSA-389957
Reactome	Protein folding	102 targets	R-HSA-391251

Name	Explore in Pharos	Explore in Source
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Metabolism of proteins	2050 targets	R-HSA-392499
Prefoldin mediated transfer of substrate to CCT/TriC	28 targets	R-HSA-389957
Protein folding	102 targets	R-HSA-391251

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (1)

Components (6)

Processes (3)

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GO Term	Evidence	Assigned by
tubulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	2	2	0	1.1	57.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
venous thromboembolism	EFO_0004286	0	1.1	57.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Chaperone
Complete proteome
Cytoplasm
Nucleus
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
venous thromboembolism

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	von Hippel-Lindau binding protein 1	MGI:1333804	22327
Dog	VHL binding protein 1	VGNC:48239	481089
Horse	VHL binding protein 1	VGNC:24890	100062203
Cow	VHL binding protein 1	VGNC:36777	508727
Pig	VHL binding protein 1		100514622

Species	Name	OMA	EggNOG	Inparanoid
Mouse	von Hippel-Lindau binding protein 1
Dog	VHL binding protein 1
Horse	VHL binding protein 1
Cow	VHL binding protein 1
Pig	VHL binding protein 1

Publication Statistics

PubMed Score 22.78

PubMed score by year

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PubTator Score 10.50

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (5)

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PMID	Year	Title