Protein Summary
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
- ENST00000286428
- ENSP00000286428
- ENSG00000155959
- PFDN3
- PFD3
- PFDN3
- VBP-1
- HIBBJ46
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.89 | ||
disease perturbation | 0.87 | ||
kinase perturbation | 0.84 | ||
histone modification site profile | 0.75 | ||
tissue sample | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.78 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 314 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.78 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 314 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (168)
PFDN4
Novelty: 0.02133605
p_int: 0.999999118
p_ni: 8.82e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PFDN2
Novelty: 0.08537716
p_int: 0.999980947
p_ni: 0.000019053
Score: 0.999
Data Source: BioPlex,STRINGDB
UBL7
Novelty: 0.20935024
p_int: 0.999962886
p_ni: 0.000037114
Score: 0.298
Data Source: BioPlex,STRINGDB
PHKB
Family: Enzyme
Novelty: 0.05506418
p_int: 0.999937384
p_ni: 0.000062615
Score: 0.229
Data Source: BioPlex,STRINGDB
COPRS
Novelty: 0.03545787
p_int: 0.99864069
p_ni: 0.00132067
p_wrong: 0.000038639
Data Source: BioPlex
SGF29
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.987097961
p_ni: 0.012902039
Score: 0.179
Data Source: BioPlex,STRINGDB
PFDN5
Novelty: 0.07673574
p_int: 0.986330474
p_ni: 0.013669526
Score: 0.999
Data Source: BioPlex,STRINGDB
SUPT6H
Novelty: 0.01099565
p_int: 0.984212318
p_ni: 0.01502848
p_wrong: 0.000759202
Score: 0.186
Data Source: BioPlex,STRINGDB
PFDN6
Novelty: 0.01632101
p_int: 0.963654549
p_ni: 0.036345451
Score: 0.999
Data Source: BioPlex,STRINGDB
PFDN1
Novelty: 0.08811378
p_int: 0.918377222
p_ni: 0.081622778
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chaperonin-mediated protein folding | ||||
Reactome | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Prefoldin mediated transfer of substrate to CCT/TriC | ||||
Reactome | Protein folding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chaperonin-mediated protein folding | ||||
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Metabolism of proteins | ||||
Prefoldin mediated transfer of substrate to CCT/TriC | ||||
Protein folding | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (1)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 57.7 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 57.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1333804 | 22327 | ||||||
Dog | VHL binding protein 1 | VGNC:48239 | 481089 | |||||
Horse | VHL binding protein 1 | VGNC:24890 | 100062203 | |||||
Cow | VHL binding protein 1 | VGNC:36777 | 508727 | |||||
Pig | VHL binding protein 1 | 100514622 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Dog | VHL binding protein 1 | |||||
Horse | VHL binding protein 1 | |||||
Cow | VHL binding protein 1 | |||||
Pig | VHL binding protein 1 | |||||
Publication Statistics
PubMed Score 22.78
PubMed score by year
PubTator Score 10.50
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
---|