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Tbio
LYZ
Lysozyme C

Protein Summary
Description
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261267
  • ENSP00000261267
  • ENSG00000090382

Symbol
  • LZM
  • LZM
  • LYZF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein complex
1
small molecule perturbation
0.83
protein domain
0.73
drug
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.79   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 829   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.79   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 829   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
88
monocyte percentage of leukocytes
2
1
2
87.7
Oral ulcer
1
1
0
1.1
80.6
granulocyte percentage of myeloid white cells
1
1
1
80.4
BMI-adjusted hip circumference
3
3
7
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
88
monocyte percentage of leukocytes
2
87.7
Oral ulcer
0
1.1
80.6
granulocyte percentage of myeloid white cells
1
80.4
BMI-adjusted hip circumference
7
79.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysozyme
VGNC:5465
450190
Macaque
lysozyme
718361
Mouse
MGI:96897
17105
Rat
RGD:3026
25211
Dog
lysozyme
VGNC:42901
474442
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysozyme
Macaque
lysozyme
Mouse
Rat
Dog
lysozyme
Protein Structure (208 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61626-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 208
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Antimicrobial peptides
Immune System
Innate Immune System
Metabolism of proteins
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (236)
1 – 10 of 236
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999137413
p_ni:  0.000862587
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.994421186
p_ni:  0.005578814
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.882833683
p_ni:  0.117166297
p_wrong:  2e-8
Score:  0.285
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.873446276
p_ni:  0.126553722
p_wrong:  2e-9
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.846851139
p_ni:  0.153148861
Data Source:  BioPlex
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.830230513
p_ni:  0.169769422
p_wrong:  6.5e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
p_int:  0.779058148
p_ni:  0.22094185
p_wrong:  2e-9
Data Source:  BioPlex
LTF
Tbio
Novelty:  0.00114254
Score:  0.973
Data Source:  STRINGDB
CHIT1
Tchem
Family:  Enzyme
Novelty:  0.00113383
Score:  0.963
Data Source:  STRINGDB
MNDA
Tbio
Novelty:  0.01991479
Score:  0.956
Data Source:  STRINGDB
Publication Statistics
PubMed Score  622.79

PubMed score by year
PubTator Score  3563.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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