Tbio SEC61A1 Protein transport protein Sec61 subunit alpha isoform 1

Protein Summary

Description

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61619
• P38378
• P57726
• Q5JPF8
• Q8N0Z4
• Q8N3U3
• Q8NC71
• Q9BU16
• Q9Y2R3
• Sec61 alpha-1

Gene Name

• SEC61A1

Ensembl ID

• ENST00000243253
• ENSP00000243253
• ENSG00000058262
• ENST00000424880
• ENSP00000411445

Symbol

• SEC61A
• HNFJ4
• SEC61
• HSEC61
• SEC61A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.99
transcription factor perturbation	0.99
hub protein	0.82
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Protein Transport Protein Sec61 Subunit Alpha Isoform 1

Protein / Membrane Traffic Protein / Protein Transport Protein Sec61 Subunit Alpha Isoform 1

DTO Classes

Protein / Transporter / Protein Transport Protein Sec61 Subunit Alpha Isoform 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.66   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.66   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0