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Tbio
SEC61A1
Protein transport protein Sec61 subunit alpha isoform 1

Protein Classes
Protein Summary
Description
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243253
  • ENSP00000243253
  • ENSG00000058262
  • ENST00000424880
  • ENSP00000411445

Symbol
  • SEC61A
  • HNFJ4
  • SEC61
  • HSEC61
  • SEC61A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
transcription factor perturbation
0.99
hub protein
0.82
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.74   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.74   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
71.9
platelet count
1
1
1
36.5
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
71.9
platelet count
1
36.5
0
1.1
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon alpha 1 subunit
VGNC:2560
460669
Mouse
MGI:1858417
53421
Rat
RGD:68321
80843
Dog
Sec61 translocon alpha 1 subunit
VGNC:49614
404006
Horse
Sec61 translocon alpha 1 subunit
VGNC:50498
100054080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon alpha 1 subunit
Mouse
Rat
Dog
Sec61 translocon alpha 1 subunit
Horse
Sec61 translocon alpha 1 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P61619-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (394)
1 – 10 of 394
RPN1
Tbio
Family:  Enzyme
Novelty:  0.00880101
Score:  0.999
Data Source:  STRINGDB
RPS14
Tbio
Novelty:  0.00576737
Score:  0.999
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.999
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.999
Data Source:  Reactome,STRINGDB
RPL9
Tbio
Novelty:  0.00845583
Score:  0.999
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.999
Data Source:  STRINGDB
SEC61G
Tbio
Novelty:  0.11375671
Score:  0.999
Data Source:  Reactome,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
Score:  0.999
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  407.74

PubMed score by year
PubTator Score  217.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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