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Tbio
NCALD
Neurocalcin-delta

Protein Summary
Description
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220931
  • ENSP00000220931
  • ENSG00000104490
  • ENST00000311028
  • ENSP00000310587
  • ENST00000395923
  • ENSP00000379256
  • ENST00000519508
  • ENSP00000430476
  • ENST00000521599
  • ENSP00000428105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
disease perturbation
0.74
transcription factor
0.71
small molecule perturbation
0.7
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.67   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.67   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
68
systolic blood pressure
1
1
1
30.2
1
1
1
14.5
Beta blocking agent use measurement
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
68
systolic blood pressure
1
30.2
1
14.5
Beta blocking agent use measurement
1
6
Pathways (7)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (107)
1 – 10 of 107
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999678201
p_ni: 0.000321798
p_wrong: 1e-9
Data Source: BioPlex
VTCN1
Tbio
Novelty: 0.00565174
p_int: 0.995375202
p_ni: 0.004621709
p_wrong: 0.000003089
Score: 0.517
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.991640802
p_ni: 0.008359195
p_wrong: 3e-9
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.928201067
p_ni: 0.071798431
p_wrong: 5.03e-7
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.914521198
p_ni: 0.085477959
p_wrong: 8.43e-7
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.88147218
p_ni: 0.118527713
p_wrong: 1.07e-7
Data Source: BioPlex
HSPBAP1
Tbio
Novelty: 0.03321047
p_int: 0.87818211
p_ni: 0.121467594
p_wrong: 0.000350296
Score: 0.305
Data Source: BioPlex,STRINGDB
CLTC
Tbio
Novelty: 0.00256674
Score: 0.939
Data Source: STRINGDB
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00578343
Score: 0.936
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.67

PubMed score by year
PubTator Score  12.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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