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Tbio
RND3
Rho-related GTP-binding protein RhoE

Protein Summary
Description
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263895
  • ENSP00000263895
  • ENSG00000115963
  • ENST00000375734
  • ENSP00000364886

Symbol
  • ARHE
  • RHO8
  • RHOE
  • ARHE
  • Rho8
  • RhoE
  • memB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
molecular function
0.91
transcription factor binding site profile
0.86
gene perturbation
0.82
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.89   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.89   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
0
2.9
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
0
2.9
26.1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (117)
1 – 10 of 117
ROCK1
Tclin
Family: Kinase
Novelty: 0.00156045
Score: 0.981
Data Source: STRINGDB
ARHGAP35
Tbio
Family: Enzyme
Novelty: 0.00970784
Score: 0.909
Data Source: STRINGDB
UBXN11
Tbio
Novelty: 0.03165477
Score: 0.829
Data Source: STRINGDB
ARHGAP5
Tbio
Family: Enzyme
Novelty: 0.03683127
Score: 0.753
Data Source: STRINGDB
PLXNB2
Tbio
Novelty: 0.01925055
Score: 0.737
Data Source: STRINGDB
ARHGDIA
Tchem
Novelty: 0.001991
Score: 0.716
Data Source: STRINGDB
WAS
Tbio
Novelty: 0.00087362
Score: 0.715
Data Source: STRINGDB
ARHGEF28
Tbio
Novelty: 0.01856808
Score: 0.693
Data Source: STRINGDB
ROCK2
Tclin
Family: Kinase
Novelty: 0.00242311
Score: 0.689
Data Source: STRINGDB
WASL
Tbio
Novelty: 0.0029314
Score: 0.68
Data Source: STRINGDB
Publication Statistics
PubMed Score  235.89

PubMed score by year
PubTator Score  45.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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