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Tbio
RHOA
Transforming protein RhoA

Protein Summary
Description
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418115
  • ENSP00000400175
  • ENSG00000067560

Symbol
  • ARH12
  • ARHA
  • RHO12
  • ARHA
  • ARH12
  • RHO12
  • RHOH12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.99
pathway
0.99
biological process
0.98
interacting protein
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5165.41   (req: < 5)
Gene RIFs: 670   (req: <= 3)
Antibodies: 606   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5165.41   (req: >= 5)
Gene RIFs: 670   (req: > 3)
Antibodies: 606   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0