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Tbio
RPL37A
60S ribosomal protein L37a

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000491306
  • ENSP00000418082
  • ENSG00000197756

Symbol
  • L37A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
interacting protein
0.93
cell type or tissue
0.91
virus perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (503)
1 – 10 of 503
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999999184
p_ni:  8.16e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
FAM199X
Tdark
Novelty:  1.32503264
p_int:  0.999880802
p_ni:  0.000119193
p_wrong:  5e-9
Data Source:  BioPlex
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.99955143
p_ni:  0.00044857
Score:  0.52
Data Source:  BioPlex,STRINGDB
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.997999187
p_ni:  0.002000813
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.996366674
p_ni:  0.003633326
Score:  0.998
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.994551463
p_ni:  0.005448537
Score:  0.836
Data Source:  BioPlex,STRINGDB
CDK12
Tchem
Family:  Kinase
Novelty:  0.0119925
p_int:  0.993485669
p_ni:  0.006514259
p_wrong:  7.2e-8
Data Source:  BioPlex
NOC3L
Tbio
Novelty:  0.05635731
p_int:  0.990041415
p_ni:  0.009958585
Score:  0.335
Data Source:  BioPlex,STRINGDB
DDX24
Tbio
Family:  Enzyme
Novelty:  0.17803446
p_int:  0.988249293
p_ni:  0.011750707
Score:  0.385
Data Source:  BioPlex,STRINGDB
NCL
Tbio
Novelty:  0.00100905
p_int:  0.986639714
p_ni:  0.013360286
Score:  0.562
Data Source:  BioPlex,STRINGDB
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter integrity
1
1
1
24.5
intelligence
1
1
0
5.6
17.8
1
1
0
1.3
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter integrity
1
24.5
intelligence
0
5.6
17.8
0
1.3
10.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L37a
106992289
Mouse
MGI:98068
19981
Horse
ribosomal protein L37a
100050696
Cow
ribosomal protein L37a
504413
Pig
60S ribosomal protein L37a
100524282
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L37a
Mouse
Horse
ribosomal protein L37a
Cow
ribosomal protein L37a
Pig
60S ribosomal protein L37a
Publication Statistics
PubMed Score 22.57
PubMed score by year
PubTator Score 8.28
PubTator score by year