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Tbio
ATP6V0D1
V-type proton ATPase subunit d 1

Protein Summary
Description
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, rece ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290949
  • ENSP00000290949
  • ENSG00000159720

Symbol
  • ATP6D
  • VPATPD
  • P39
  • VATX
  • VMA6
  • ATP6D
  • ATP6DV
  • VPATPD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.96
transcription factor binding site profile
0.94
disease perturbation
0.9
biological process
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
26.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
26.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit d1
VGNC:13667
741872
Mouse
MGI:1201778
11972
Rat
RGD:1306159
291969
Dog
ATPase H+ transporting V0 subunit d1
VGNC:38273
479685
Horse
ATPase H+ transporting V0 subunit d1
VGNC:15672
100053316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit d1
Mouse
Rat
Dog
ATPase H+ transporting V0 subunit d1
Horse
ATPase H+ transporting V0 subunit d1
Pathways (27)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Protein-Protein Interactions (155)
1 – 10 of 155
MVD
Tchem
Family: Enzyme
Novelty: 0.0067581
p_int: 0.999999995
p_wrong: 5e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.999999991
p_ni: 9e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
p_int: 0.999999738
p_ni: 2.62e-7
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
LEPR
Tclin
Novelty: 0.00070587
p_int: 0.999999698
p_ni: 2.69e-7
p_wrong: 3.4e-8
Score: 0.293
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.999995432
p_ni: 0.000004568
Score: 0.18
Data Source: BioPlex,STRINGDB
ATP6V0A1
Tbio
Family: Enzyme
Novelty: 0.02009317
p_int: 0.999989134
p_ni: 0.000010866
Score: 0.998
Data Source: BioPlex,STRINGDB
TMEM199
Tbio
Novelty: 0.05799147
p_int: 0.999984702
p_ni: 0.000015298
Score: 0.992
Data Source: BioPlex,STRINGDB
SNX25
Tbio
Novelty: 0.15818269
p_int: 0.999949907
p_ni: 0.000048718
p_wrong: 0.000001375
Score: 0.197
Data Source: BioPlex,STRINGDB
VMA21
Tdark
Family: Enzyme
Novelty: 0.46129032
p_int: 0.999936914
p_ni: 0.000063083
p_wrong: 2e-9
Score: 0.765
Data Source: BioPlex,STRINGDB
ATP6V0C
Tbio
Family: Enzyme
Novelty: 0.01142874
p_int: 0.999855128
p_ni: 0.000144872
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.80

PubMed score by year
PubTator Score  6.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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