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Tbio
RPL27
60S ribosomal protein L27

Protein Summary
Description
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253788
  • ENSP00000253788
  • ENSG00000131469
  • ENST00000589037
  • ENSP00000467587
  • ENST00000589913
  • ENSP00000464813

Symbol
  • L27
  • DBA16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
small molecule perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (446)
1 – 10 of 446
CNBP
Tbio
Novelty: 0.0006668
p_int: 0.987708095
p_ni: 0.012291905
Score: 0.62
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0256669
p_int: 0.961247098
p_ni: 0.038752902
Score: 0.999
Data Source: BioPlex,STRINGDB
PUM3
Tbio
Novelty: 0.01145585
p_int: 0.881925799
p_ni: 0.118074201
Score: 0.652
Data Source: BioPlex,STRINGDB
H1FOO
Tbio
Novelty: 0.02925688
p_int: 0.878429954
p_ni: 0.121570046
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.0322797
p_int: 0.858120168
p_ni: 0.141879832
Score: 0.999
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03125092
p_int: 0.855228233
p_ni: 0.144771767
Score: 0.999
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.00929224
p_int: 0.813829025
p_ni: 0.186170975
Score: 0.697
Data Source: BioPlex,STRINGDB
MECP2
Tchem
Family: TF
Novelty: 0.00058175
p_int: 0.811781078
p_ni: 0.188218922
Data Source: BioPlex
SART3
Tbio
Novelty: 0.02812047
p_int: 0.788847422
p_ni: 0.211152578
Data Source: BioPlex
KNOP1
Tdark
Novelty: 1.2
p_int: 0.775245896
p_ni: 0.224754104
Score: 0.534
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  46.17

PubMed score by year
PubTator Score  37.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKS
1-70
FVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
70-136
MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF