You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAGOH
Protein mago nashi homolog

Protein Summary
Description
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371466
  • ENSP00000360521
  • ENSG00000162385
  • ENST00000371470
  • ENSP00000360525

Symbol
  • MAGOHA
  • MAGOH1
  • MAGOHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.94
histone modification site profile
0.86
kinase perturbation
0.81
transcription factor binding site profile
0.8
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (391)
PYM1
Tbio
Novelty:  0.04117785
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
SCRN3
Tbio
Family:  Enzyme
Novelty:  0.03516382
p_int:  0.999984358
p_ni:  0.000015636
p_wrong:  6e-9
Score:  0.528
Data Source:  BioPlex,STRINGDB
DFFB
Tbio
Novelty:  0.00475349
p_int:  0.999956925
p_ni:  0.000035481
p_wrong:  0.000007594
Score:  0.719
Data Source:  BioPlex,STRINGDB
RBM8A
Tbio
Novelty:  0.00052175
p_int:  0.999180022
p_ni:  0.000819978
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.980776463
p_ni:  0.019223537
Score:  0.186
Data Source:  BioPlex,STRINGDB
CASC3
Tbio
Novelty:  0.03935581
p_int:  0.979421419
p_ni:  0.020578532
p_wrong:  4.9e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.946453986
p_ni:  0.053546014
Score:  0.187
Data Source:  BioPlex,STRINGDB
SARNP
Tbio
Novelty:  0.00987312
p_int:  0.913207588
p_ni:  0.086792412
Score:  0.969
Data Source:  BioPlex,STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.882531124
p_ni:  0.117468873
p_wrong:  3e-9
Data Source:  BioPlex
PNN
Tbio
Novelty:  0.01395394
p_int:  0.811493925
p_ni:  0.188506075
Score:  0.771
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Gene expression (Transcription)
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
84
metabolite measurement
1
2
2
76.5
cortical thickness
1
1
0
11.1
69.4
brain measurement
1
1
0
10.6
68.1
tuberculin skin test reactivity measurement
1
1
1
64.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
84
metabolite measurement
2
76.5
cortical thickness
0
11.1
69.4
brain measurement
0
10.6
68.1
tuberculin skin test reactivity measurement
1
64.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mago homolog, exon junction complex subunit
VGNC:11529
104001049
Macaque
mago homolog, exon junction complex core component
714261
Mouse
MGI:1330312
17149
Rat
RGD:1305174
298385
Horse
mago homolog, exon junction complex core component
100060994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mago homolog, exon junction complex subunit
Macaque
mago homolog, exon junction complex core component
Mouse
Rat
Horse
mago homolog, exon junction complex core component
Publication Statistics
PubMed Score 29.16
PubMed score by year
PubTator Score 17.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title