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Tbio
RPL15
60S ribosomal protein L15

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307839
  • ENSP00000309334
  • ENSG00000174748
  • ENST00000354811
  • ENSP00000346867
  • ENST00000413699
  • ENSP00000416692
  • ENST00000415719
  • ENSP00000388529
  • ENST00000435882
  • ENSP00000390193
  • ENST00000456530
  • ENSP00000398788
  • ENST00000611050
  • ENSP00000483260
  • ENST00000644185
  • ENSP00000493759

Symbol
  • EC45
  • L15
  • EC45
  • DBA12
  • RPL10
  • RPLY10
  • RPYL10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
transcription factor perturbation
0.97
virus perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
12
5
7.1
89.1
mathematical ability
3
3
3
72
cognitive function measurement
3
2
3
68.5
self reported educational attainment
2
2
2
65.7
smoking status measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
7.1
89.1
mathematical ability
3
72
cognitive function measurement
3
68.5
self reported educational attainment
2
65.7
smoking status measurement
1
15.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L15
VGNC:2543
750112
Macaque
ribosomal protein L15-like
716888
Mouse
MGI:1913730
66480
Rat
RGD:621181
245981
Dog
ribosomal protein L15
VGNC:52901
477046
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L15
Macaque
ribosomal protein L15-like
Mouse
Rat
Dog
ribosomal protein L15
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61313-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (508)
1 – 10 of 508
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.9999175
p_ni:  0.000070954
p_wrong:  0.000011546
Data Source:  BioPlex
FAM192A
Tdark
Novelty:  0.46220707
p_int:  0.99982767
p_ni:  0.00017233
Data Source:  BioPlex
CLNS1A
Tbio
Novelty:  0.01824362
p_int:  0.999227419
p_ni:  0.000772581
Score:  0.266
Data Source:  BioPlex,STRINGDB
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
p_int:  0.997542487
p_ni:  0.002457513
Score:  0.413
Data Source:  BioPlex,STRINGDB
DCAF1
Tbio
Novelty:  0.0170232
p_int:  0.997490652
p_ni:  0.002509348
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.995674527
p_ni:  0.004325473
Score:  0.204
Data Source:  BioPlex,STRINGDB
PWP1
Tbio
Novelty:  0.07040539
p_int:  0.992815623
p_ni:  0.007184377
Score:  0.598
Data Source:  BioPlex,STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.987771427
p_ni:  0.012228573
Score:  0.164
Data Source:  BioPlex,STRINGDB
NLE1
Tbio
Novelty:  0.03831535
p_int:  0.98568703
p_ni:  0.014312964
p_wrong:  6e-9
Score:  0.754
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.968450052
p_ni:  0.031549948
Data Source:  BioPlex
Publication Statistics
PubMed Score  39.26

PubMed score by year
PubTator Score  9.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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