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Tbio
PSME3
Proteasome activator complex subunit 3

Protein Summary
Description
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subuni ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293362
  • ENSP00000293362
  • ENSG00000131467
  • ENST00000441946
  • ENSP00000409487
  • ENST00000590720
  • ENSP00000466794

Symbol
  • Ki
  • PA28G
  • HEL-S-283
  • PA28gamma
  • REG-GAMMA
  • PA28-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
biological process
0.99
interacting protein
0.98
virus
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.44   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.44   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (398)
SNAPC1
Tbio
Novelty:  0.18444701
p_int:  0.999999694
p_ni:  1.5e-7
p_wrong:  1.56e-7
Score:  0.542
Data Source:  BioPlex,STRINGDB
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.999999676
p_ni:  3.24e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
SNAPC4
Tbio
Family:  TF
Novelty:  0.09720791
p_int:  0.999998374
p_ni:  0.000001619
p_wrong:  7e-9
Score:  0.671
Data Source:  BioPlex,STRINGDB
SNAPC3
Tbio
Novelty:  0.11748003
p_int:  0.99999763
p_ni:  0.000001516
p_wrong:  8.54e-7
Score:  0.664
Data Source:  BioPlex,STRINGDB
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
p_int:  0.999994775
p_ni:  0.000005225
Data Source:  BioPlex
ZBTB9
Tdark
Novelty:  0.95590016
p_int:  0.999990388
p_ni:  0.000008241
p_wrong:  0.000001371
Data Source:  BioPlex
MBTD1
Tbio
Family:  Epigenetic
Novelty:  0.11651052
p_int:  0.999979751
p_ni:  0.000020249
Data Source:  BioPlex
CHD8
Tbio
Family:  Epigenetic
Novelty:  0.01177693
p_int:  0.999949227
p_ni:  0.000050773
Score:  0.165
Data Source:  BioPlex,STRINGDB
CBX2
Tchem
Family:  Epigenetic
Novelty:  0.01952928
p_int:  0.999943786
p_ni:  0.000056213
p_wrong:  1e-9
Score:  0.238
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.999828537
p_ni:  0.000171463
Score:  0.187
Data Source:  BioPlex,STRINGDB
Pathways (153)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
4
4
76.6
waist-hip ratio
1
3
3
72.9
waist circumference
1
2
2
43.8
triglyceride measurement
1
1
1
33.1
2
1
1
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
76.6
waist-hip ratio
3
72.9
waist circumference
2
43.8
triglyceride measurement
1
33.1
1
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome activator subunit 3
VGNC:9545
740582
Macaque
proteasome activator subunit 3
711900
Mouse
MGI:1096366
19192
Rat
RGD:1306996
287716
Dog
proteasome activator subunit 3
VGNC:45118
480512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome activator subunit 3
Macaque
proteasome activator subunit 3
Mouse
Rat
Dog
proteasome activator subunit 3
Publication Statistics
PubMed Score 127.44
PubMed score by year
PubTator Score 50.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title