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Tbio
RPS3A
40S ribosomal protein S3a

Protein Summary
Description
May play a role during erythropoiesis through regulation of transcription factor DDIT3. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274065
  • ENSP00000346050
  • ENSG00000145425

Symbol
  • FTE1
  • MFTL
  • S3A
  • FTE1
  • MFTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
disease perturbation
0.98
transcription factor binding site profile
0.94
small molecule perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (566)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.971213669
p_ni:  0.028786331
Score:  0.424
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.968263446
p_ni:  0.031736554
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.960341516
p_ni:  0.039658484
Score:  0.999
Data Source:  BioPlex,STRINGDB
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.937609639
p_ni:  0.062390361
Score:  0.974
Data Source:  BioPlex,STRINGDB
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.930413749
p_ni:  0.069586251
Score:  0.197
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.924598232
p_ni:  0.075401768
Score:  0.491
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.916174769
p_ni:  0.083825231
Score:  0.364
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.908338481
p_ni:  0.091661519
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.907212787
p_ni:  0.092787213
Score:  0.999
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.892112247
p_ni:  0.107887753
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
1.3
gut microbiome measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1.3
gut microbiome measurement
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1202063
20091
Rat
RGD:62078
29288
Dog
ribosomal protein S3A
403677
Horse
ribosomal protein S3A
VGNC:49260
100062429
Cow
ribosomal protein S3A
282053
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ribosomal protein S3A
Horse
ribosomal protein S3A
Cow
ribosomal protein S3A
Publication Statistics
PubMed Score 96.61
PubMed score by year
PubTator Score 28.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title