Tbio MAX Protein max

Protein Summary

Description

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P61244
• A6NH73
• A8K265
• A8K4G4
• A8K824
• P25912
• P52163
• Q14803
• Q96CY8

Gene Name

• MAX

Ensembl ID

• ENST00000246163
• ENSP00000246163
• ENSG00000125952
• ENST00000284165
• ENSP00000284165
• ENST00000341653
• ENSP00000342482
• ENST00000358402
• ENSP00000351175
• ENST00000358664
• ENSP00000351490
• ENST00000394606
• ENSP00000378104
• ENST00000553928
• ENSP00000451907
• ENST00000556979
• ENSP00000452378
• ENST00000618858
• ENSP00000480127

Symbol

• BHLHD4
• bHLHd4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.95
transcription factor binding site profile	0.94
transcription factor	0.9
hub protein	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Protein Max

Protein / Nucleic Acid Binding / Protein Max

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Protein Max

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.88   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 511   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.88   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (167)

Explore Interacting Targets

1 – 10 of 167

• See Interactions on String-DB

MNT

Tbio

Family:  TF

Novelty:  0.0088423

p_int:  1

Score:  0.436

Data Source:  BioPlex,STRINGDB

MYC

Tchem

Family:  TF

Novelty:  0.00005734

p_int:  0.999999997

p_ni:  3e-9

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

E2F6

Tbio

Family:  TF

Novelty:  0.00753541

p_int:  0.999998849

p_ni:  0.000001147

p_wrong:  4e-9

Score:  0.928

Data Source:  BioPlex,Reactome,STRINGDB

MXI1

Tbio

Family:  TF

Novelty:  0.00455907

p_int:  0.999996691

p_ni:  3e-9

p_wrong:  0.000003306

Score:  0.842

Data Source:  BioPlex,STRINGDB

L3MBTL2

Tbio

Family:  Epigenetic

Novelty:  0.11193867

p_int:  0.999996367

p_ni:  0.000003633

Score:  0.946

Data Source:  BioPlex,Reactome,STRINGDB

MGA

Tbio

Family:  TF

Novelty:  0.08965274

p_int:  0.999990365

p_ni:  0.000009635

Score:  0.949

Data Source:  BioPlex,Reactome,STRINGDB

TFDP1

Tbio

Family:  TF

Novelty:  0.02026858

p_int:  0.999986133

p_ni:  0.00000937

p_wrong:  0.000004497

Score:  0.931

Data Source:  BioPlex,Reactome,STRINGDB

MXD4

Tbio

Family:  TF

Novelty:  0.04724453

p_int:  0.999977653

p_ni:  1e-9

p_wrong:  0.000022346

Score:  0.72

Data Source:  BioPlex,STRINGDB

PCGF6

Tbio

Novelty:  0.07032909

p_int:  0.999835245

p_ni:  0.000164721

p_wrong:  3.4e-8

Score:  0.936

Data Source:  BioPlex,Reactome,STRINGDB

EP400

Tbio

Novelty:  0.02013098

p_int:  0.99958421

p_ni:  0.00041579

Score:  0.41

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (7)

Explore Nearest Tclin Targets

Upstream (3)

Downstream (4)

1 – 3 of 3

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  2

1: MAPK signaling pathway

2: Pathways in cancer

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  2

1: MAPK signaling pathway

2: Pathways in cancer

RARA

Tclin

Family:  Nuclear Receptor

KEGG Distance:  3

Common Pathways:  2

1: Transcriptional misregulation in cancer

2: Pathways in cancer

Pathways (30)

Reactome (13)

KEGG (4)

PathwayCommons (7)

WikiPathways (6)

Cell Cycle (R-HSA-1640170)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Reactome	Cyclin E associated events during G1/S transition	84 targets	R-HSA-69202
Reactome	G0 and Early G1	27 targets	R-HSA-1538133

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Cyclin E associated events during G1/S transition	84 targets	R-HSA-69202
G0 and Early G1	27 targets	R-HSA-1538133

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (12)

Components (9)

Processes (12)

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Items per page:

10

1 – 10 of 12

GO Term	Evidence	Assigned by
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	UniProtKB
DNA binding	Inferred from Mutant Phenotype (IMP)	CAFA
E-box binding	Inferred from Mutant Phenotype (IMP)	CAFA
protein homodimerization activity	Inferred from Mutant Phenotype (IMP)	CAFA
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc
transcription coactivator activity	Traceable Author Statement (TAS)	ProtInc
transcription coregulator activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (20)

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1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	4	3	4		98
reticulocyte measurement	EFO_0010700	3	2	3		90.2
mean corpuscular volume	EFO_0004526	2	3	3		89.9
reticulocyte count	EFO_0007986	2	2	2		86.6
red blood cell density measurement	EFO_0007978	1	1	1		82.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	4		98
reticulocyte measurement	EFO_0010700	3		90.2
mean corpuscular volume	EFO_0004526	3		89.9
reticulocyte count	EFO_0007986	2		86.6
red blood cell density measurement	EFO_0007978	1		82.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Alternative splicing
Cell projection
Complete proteome
Disease mutation
DNA-binding
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
body height
eosinophil count
eosinophil percentage of leukocytes
erythrocyte count
erythrocyte measurement
hemoglobin measurement
leukocyte count
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MYC associated factor X	VGNC:3386	452972
Macaque	MYC associated factor X		708228
Mouse	Max protein	MGI:96921	17187
Rat	MYC associated factor X	RGD:621101	60661
Dog	MYC associated factor X	VGNC:43045	609969

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MYC associated factor X
Macaque	MYC associated factor X
Mouse	Max protein
Rat	MYC associated factor X
Dog	MYC associated factor X

Publication Statistics

PubMed Score 80.88

PubMed score by year

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PubTator Score 14.35

PubTator score by year

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Related Publications

Text Mined References (122)

GeneRif Annotations (42)

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PMID	Year	Title