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Tbio
MAX
Protein max

Protein Summary
Description
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246163
  • ENSP00000246163
  • ENSG00000125952
  • ENST00000284165
  • ENSP00000284165
  • ENST00000341653
  • ENSP00000342482
  • ENST00000358402
  • ENSP00000351175
  • ENST00000358664
  • ENSP00000351490
  • ENST00000394606
  • ENSP00000378104
  • ENST00000553928
  • ENSP00000451907
  • ENST00000556979
  • ENSP00000452378
  • ENST00000618858
  • ENSP00000480127

Symbol
  • BHLHD4
  • bHLHd4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.95
transcription factor binding site profile
0.94
transcription factor
0.9
hub protein
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.19   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 511   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.19   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
3
4
94.8
mean corpuscular volume
2
2
2
84.4
red blood cell density measurement
1
1
1
81.8
mean platelet volume
3
1
3
81.5
reticulocyte measurement
3
2
3
67.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
94.8
mean corpuscular volume
2
84.4
red blood cell density measurement
1
81.8
mean platelet volume
3
81.5
reticulocyte measurement
3
67.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYC associated factor X
VGNC:3386
452972
Macaque
MYC associated factor X
708228
Mouse
MGI:96921
17187
Rat
RGD:621101
60661
Dog
MYC associated factor X
VGNC:43045
609969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYC associated factor X
Macaque
MYC associated factor X
Mouse
Rat
Dog
MYC associated factor X
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61244-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
G0 and Early G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
G0 and Early G1
Gene Ontology Terms (33)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (167)
1 – 10 of 167
MNT
Tbio
Family: TF
Novelty: 0.0088423
p_int: 1
Score: 0.436
Data Source: BioPlex,STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
p_int: 0.999999997
p_ni: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
E2F6
Tbio
Family: TF
Novelty: 0.00753541
p_int: 0.999998849
p_ni: 0.000001147
p_wrong: 4e-9
Score: 0.928
Data Source: BioPlex,Reactome,STRINGDB
MXI1
Tbio
Family: TF
Novelty: 0.00455907
p_int: 0.999996691
p_ni: 3e-9
p_wrong: 0.000003306
Score: 0.842
Data Source: BioPlex,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999996367
p_ni: 0.000003633
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
MGA
Tbio
Family: TF
Novelty: 0.08965274
p_int: 0.999990365
p_ni: 0.000009635
Score: 0.949
Data Source: BioPlex,Reactome,STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02026858
p_int: 0.999986133
p_ni: 0.00000937
p_wrong: 0.000004497
Score: 0.931
Data Source: BioPlex,Reactome,STRINGDB
MXD4
Tbio
Family: TF
Novelty: 0.04724453
p_int: 0.999977653
p_ni: 1e-9
p_wrong: 0.000022346
Score: 0.72
Data Source: BioPlex,STRINGDB
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.999835245
p_ni: 0.000164721
p_wrong: 3.4e-8
Score: 0.936
Data Source: BioPlex,Reactome,STRINGDB
EP400
Tbio
Novelty: 0.02013098
p_int: 0.99958421
p_ni: 0.00041579
Score: 0.41
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  79.19

PubMed score by year
PubTator Score  14.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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