Protein Summary
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associ ...more
- ENST00000246163
- ENSP00000246163
- ENSG00000125952
- ENST00000284165
- ENSP00000284165
- ENST00000341653
- ENSP00000342482
- ENST00000358402
- ENSP00000351175
- ENST00000358664
- ENSP00000351490
- ENST00000394606
- ENSP00000378104
- ENST00000553928
- ENSP00000451907
- ENST00000556979
- ENSP00000452378
- ENST00000618858
- ENSP00000480127
- BHLHD4
- bHLHd4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.95 | ||
transcription factor binding site profile | 0.94 | ||
transcription factor | 0.9 | ||
hub protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 149.32 (req: < 5)
Gene RIFs: 62 (req: <= 3)
Antibodies: 511 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 149.32 (req: >= 5)
Gene RIFs: 62 (req: > 3)
Antibodies: 511 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0