Protein Classes
Protein Summary
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associ ...more
- ENST00000246163
- ENSP00000246163
- ENSG00000125952
- ENST00000284165
- ENSP00000284165
- ENST00000341653
- ENSP00000342482
- ENST00000358402
- ENSP00000351175
- ENST00000358664
- ENSP00000351490
- ENST00000394606
- ENSP00000378104
- ENST00000553928
- ENSP00000451907
- ENST00000556979
- ENSP00000452378
- ENST00000618858
- ENSP00000480127
- BHLHD4
- bHLHd4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.95 | ||
transcription factor binding site profile | 0.94 | ||
transcription factor | 0.9 | ||
hub protein | 0.85 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.19 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 511 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.19 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 511 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 3 | 4 | 94.8 | |||||
mean corpuscular volume | 2 | 2 | 2 | 84.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 81.8 | |||||
mean platelet volume | 3 | 1 | 3 | 81.5 | |||||
reticulocyte measurement | 3 | 2 | 3 | 67.6 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 94.8 | |||||
mean corpuscular volume | 2 | 84.4 | |||||
red blood cell density measurement | 1 | 81.8 | |||||
mean platelet volume | 3 | 81.5 | |||||
reticulocyte measurement | 3 | 67.6 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MYC associated factor X | VGNC:3386 | 452972 | |||||
Macaque | MYC associated factor X | 708228 | ||||||
Mouse | MGI:96921 | 17187 | ||||||
Rat | RGD:621101 | 60661 | ||||||
Dog | MYC associated factor X | VGNC:43045 | 609969 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MYC associated factor X | |||||
Macaque | MYC associated factor X | |||||
Mouse | ||||||
Rat | ||||||
Dog | MYC associated factor X | |||||
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (13)
KEGG (4)
PathwayCommons (7)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Reactome | Cyclin E associated events during G1/S transition | ||||
Reactome | G0 and Early G1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Cyclin E associated events during G1/S transition | ||||
G0 and Early G1 | ||||
Gene Ontology Terms (33)
Functions (12)
Components (9)
Processes (12)
Items per page:
10
1 – 10 of 12
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (167)
1 – 10 of 167
MNT
Family: TF
Novelty: 0.0088423
p_int: 1
Score: 0.436
Data Source: BioPlex,STRINGDB
MYC
Family: TF
Novelty: 0.00005734
p_int: 0.999999997
p_ni: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
E2F6
Family: TF
Novelty: 0.00753541
p_int: 0.999998849
p_ni: 0.000001147
p_wrong: 4e-9
Score: 0.928
Data Source: BioPlex,Reactome,STRINGDB
MXI1
Family: TF
Novelty: 0.00455907
p_int: 0.999996691
p_ni: 3e-9
p_wrong: 0.000003306
Score: 0.842
Data Source: BioPlex,STRINGDB
L3MBTL2
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999996367
p_ni: 0.000003633
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
MGA
Family: TF
Novelty: 0.08965274
p_int: 0.999990365
p_ni: 0.000009635
Score: 0.949
Data Source: BioPlex,Reactome,STRINGDB
TFDP1
Family: TF
Novelty: 0.02026858
p_int: 0.999986133
p_ni: 0.00000937
p_wrong: 0.000004497
Score: 0.931
Data Source: BioPlex,Reactome,STRINGDB
MXD4
Family: TF
Novelty: 0.04724453
p_int: 0.999977653
p_ni: 1e-9
p_wrong: 0.000022346
Score: 0.72
Data Source: BioPlex,STRINGDB
PCGF6
Novelty: 0.07032909
p_int: 0.999835245
p_ni: 0.000164721
p_wrong: 3.4e-8
Score: 0.936
Data Source: BioPlex,Reactome,STRINGDB
EP400
Novelty: 0.02013098
p_int: 0.99958421
p_ni: 0.00041579
Score: 0.41
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 79.19
PubMed score by year
PubTator Score 14.35
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait