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Tbio
YPEL3
Protein yippee-like 3

Protein Summary
Description
Involved in proliferation and apoptosis in myeloid precursor cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398838
  • ENSP00000381818
  • ENSG00000090238
  • ENST00000398841
  • ENSP00000381821
  • ENST00000563788
  • ENSP00000457976
  • ENST00000566595
  • ENSP00000456427
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
disease perturbation
0.79
small molecule perturbation
0.79
transcription factor binding site profile
0.69
gene perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.74   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.74   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
1 – 10 of 30
FBXL2
Tbio
Novelty:  0.06436294
p_int:  0.999924038
p_ni:  7.1e-8
p_wrong:  0.000075892
Score:  0.69
Data Source:  BioPlex,STRINGDB
FBXL20
Tbio
Novelty:  0.092544
p_int:  0.999916159
p_ni:  0.000039504
p_wrong:  0.000044337
Score:  0.631
Data Source:  BioPlex,STRINGDB
WDR26
Tbio
Novelty:  0.04140166
Score:  0.716
Data Source:  STRINGDB
ASPHD1
Tdark
Family:  Enzyme
Novelty:  0.97195692
Score:  0.714
Data Source:  STRINGDB
HIRIP3
Tdark
Novelty:  0.34456295
Score:  0.694
Data Source:  STRINGDB
FAM57B
Tdark
Novelty:  0.54016149
Score:  0.683
Data Source:  STRINGDB
GDPD3
Tbio
Family:  Enzyme
Novelty:  0.18121762
Score:  0.679
Data Source:  STRINGDB
C16orf92
Tdark
Novelty:  3.33740474
Score:  0.669
Data Source:  STRINGDB
DOC2A
Tbio
Novelty:  0.07489914
Score:  0.639
Data Source:  STRINGDB
KCTD13
Tbio
Novelty:  0.07000508
Score:  0.62
Data Source:  STRINGDB
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
3
6
94.7
mean corpuscular volume
3
2
3
94
body mass index
3
3
3
92
red blood cell density measurement
2
1
2
87.3
mean corpuscular hemoglobin concentration
1
1
1
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
6
94.7
mean corpuscular volume
3
94
body mass index
3
92
red blood cell density measurement
2
87.3
mean corpuscular hemoglobin concentration
1
87
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
yippee like 3
VGNC:13811
467945
Macaque
yippee like 3
708740
Mouse
MGI:1913340
66090
Rat
RGD:1564579
293491
Dog
yippee like 3
VGNC:48499
100687196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
yippee like 3
Macaque
yippee like 3
Mouse
Rat
Dog
yippee like 3
Publication Statistics
PubMed Score 9.74
PubMed score by year
PubTator Score 4.33
PubTator score by year