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Tbio
RAP2B
Ras-related protein Rap-2b

Protein Summary
Description
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323534
  • ENSP00000319096
  • ENSG00000181467
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.94
transcription factor perturbation
0.88
kinase perturbation
0.81
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.26   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.26   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (216)
RAPGEF3
Tchem
Novelty:  0.00199705
Score:  0.959
Data Source:  STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.939
Data Source:  STRINGDB
PLCE1
Tbio
Family:  Enzyme
Novelty:  0.0070258
Score:  0.936
Data Source:  STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.927
Data Source:  STRINGDB
COPB1
Tbio
Novelty:  0.0078407
Score:  0.923
Data Source:  STRINGDB
SNAP23
Tbio
Novelty:  0.0065371
Score:  0.921
Data Source:  STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.921
Data Source:  STRINGDB
PLAU
Tchem
Family:  Enzyme
Novelty:  0.0005322
Score:  0.92
Data Source:  STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
Score:  0.917
Data Source:  STRINGDB
RAB14
Tbio
Family:  Enzyme
Novelty:  0.01876172
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
5.7
lymphocyte percentage of leukocytes
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
5.7
lymphocyte percentage of leukocytes
1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAP2B, member of RAS oncogene family
711055
Mouse
MGI:1921262
74012
Rat
RGD:620591
170923
Cow
RAP2B, member of RAS oncogene family
VGNC:33720
784133
Opossum
RAP2B, member of RAS oncogene family
100020398
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAP2B, member of RAS oncogene family
Mouse
Rat
Cow
RAP2B, member of RAS oncogene family
Opossum
RAP2B, member of RAS oncogene family
Publication Statistics
PubMed Score 197.26
PubMed score by year
PubTator Score 31.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title