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Tbio
RAP2B
Ras-related protein Rap-2b

Protein Summary
Description
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323534
  • ENSP00000319096
  • ENSG00000181467
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.94
transcription factor perturbation
0.88
kinase perturbation
0.81
molecular function
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.03   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.03   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAP2B, member of RAS oncogene family
711055
Mouse
MGI:1921262
74012
Rat
RGD:620591
170923
Cow
RAP2B, member of RAS oncogene family
VGNC:33720
784133
Opossum
RAP2B, member of RAS oncogene family
100020398
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAP2B, member of RAS oncogene family
Mouse
Rat
Cow
RAP2B, member of RAS oncogene family
Opossum
RAP2B, member of RAS oncogene family
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61225-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (216)
1 – 10 of 216
RAPGEF3
Tchem
Novelty: 0.00199705
Score: 0.959
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.939
Data Source: STRINGDB
PLCE1
Tbio
Family: Enzyme
Novelty: 0.0070258
Score: 0.936
Data Source: STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.927
Data Source: STRINGDB
COPB1
Tbio
Novelty: 0.0078407
Score: 0.923
Data Source: STRINGDB
SNAP23
Tbio
Novelty: 0.0065371
Score: 0.921
Data Source: STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.921
Data Source: STRINGDB
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
Score: 0.92
Data Source: STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
Score: 0.917
Data Source: STRINGDB
RAB14
Tbio
Family: Enzyme
Novelty: 0.01876172
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  195.03

PubMed score by year
PubTator Score  31.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer