Tbio RAP1B Ras-related protein Rap-1b

Protein Summary

Description

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P61224
• B2R5Z2
• B4DQI8
• B4DW74
• B4DW94
• P09526
• Q502X3
• Q5TZR4
• Q6DCA1
• Q6LES0

Gene Name

• RAP1B

Ensembl ID

• ENST00000250559
• ENSP00000250559
• ENSG00000127314
• ENST00000341355
• ENSP00000441275
• ENST00000393436
• ENSP00000377085
• ENST00000450214
• ENSP00000399986
• ENST00000537460
• ENSP00000439966
• ENST00000539091
• ENSP00000444830
• ENST00000540209
• ENSP00000446318
• ENST00000542145
• ENSP00000440014

Symbol

• K-REV
• RAL1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
disease perturbation	0.95
molecular function	0.95
interacting protein	0.92
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Ras-related Protein Rap-1b

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Ras-related Protein Rap-1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.41   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.41   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0