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Tbio
RAP1B
Ras-related protein Rap-1b

Protein Summary
Description
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250559
  • ENSP00000250559
  • ENSG00000127314
  • ENST00000341355
  • ENSP00000441275
  • ENST00000393436
  • ENSP00000377085
  • ENST00000450214
  • ENSP00000399986
  • ENST00000537460
  • ENSP00000439966
  • ENST00000539091
  • ENSP00000444830
  • ENST00000540209
  • ENSP00000446318
  • ENST00000542145
  • ENSP00000440014

Symbol
  • K-REV
  • RAL1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.95
molecular function
0.95
interacting protein
0.92
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.96   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.96   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (368)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Gene Ontology Terms (25)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (278)
1 – 10 of 278
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.04627419
p_int: 0.99524063
p_ni: 0.00475937
Score: 0.604
Data Source: BioPlex,STRINGDB
RGL1
Tbio
Novelty: 0.01382117
p_int: 0.994434569
p_ni: 0.005149088
p_wrong: 0.000416343
Score: 0.486
Data Source: BioPlex,STRINGDB
PLPPR1
Tdark
Family: Enzyme
Novelty: 0.67039106
p_int: 0.982282179
p_ni: 0.017717819
p_wrong: 2e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
SCYL3
Tdark
Family: Kinase
Novelty: 0.31818182
p_int: 0.960916976
p_ni: 0.038750766
p_wrong: 0.000332258
Score: 0.225
Data Source: BioPlex,STRINGDB
GRPR
Tchem
Family: GPCR
Novelty: 0.00322431
p_int: 0.885078745
p_ni: 0.114920382
p_wrong: 8.74e-7
Data Source: BioPlex
RASL10A
Tbio
Family: Enzyme
Novelty: 0.21649485
p_int: 0.87098765
p_ni: 0.12901235
Score: 0.871
Data Source: BioPlex,STRINGDB
PI4K2A
Tbio
Family: Kinase
Novelty: 0.00759288
p_int: 0.857317385
p_ni: 0.142643535
p_wrong: 0.000039081
Data Source: BioPlex
TMEM206
Tdark
Novelty: 0.38095238
p_int: 0.857046212
p_ni: 0.142952664
p_wrong: 0.000001123
Data Source: BioPlex
PLTP
Tbio
Novelty: 0.00296163
p_int: 0.836138073
p_ni: 0.163860648
p_wrong: 0.000001279
Score: 0.165
Data Source: BioPlex,STRINGDB
RAP1GAP
Tbio
Family: Enzyme
Novelty: 0.01375276
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  507.96

PubMed score by year
PubTator Score  80

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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