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Tbio
POLR2F
DNA-directed RNA polymerases I, II, and III subunit RPABC2

Protein Summary
Description
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in mu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442738
  • ENSP00000403852
  • ENSG00000100142

Symbol
  • POLRF
  • RPB6
  • POLRF
  • RPC15
  • RPABC2
  • RPB14.4
  • HRBP14.4
  • RPABC14.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.9
biological process
0.87
kinase perturbation
0.81
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (696)
1 – 10 of 696
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.995942495
p_ni:  0.004057505
Score:  0.999
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.924457548
p_ni:  0.075542452
Score:  0.179
Data Source:  BioPlex,STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.859883183
p_ni:  0.140116337
p_wrong:  4.8e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.843388892
p_ni:  0.156611108
Score:  0.81
Data Source:  BioPlex,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.999
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.999
Data Source:  STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.999
Data Source:  STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.999
Data Source:  STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
Score:  0.999
Data Source:  STRINGDB
POLR2H
Tbio
Family:  Enzyme
Novelty:  0.04008409
Score:  0.999
Data Source:  STRINGDB
Pathways (103)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 91
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
67.1
red blood cell distribution width
1
1
1
55.2
2
1
0
1.1
49.5
smoking status measurement
2
1
2
46.9
atrophic macular degeneration
1
1
0
1.1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
67.1
red blood cell distribution width
1
55.2
0
1.1
49.5
smoking status measurement
2
46.9
atrophic macular degeneration
0
1.1
46.5
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit F
VGNC:8865
458824
Mouse
MGI:1349393
69833
Rat
RGD:708567
83503
Dog
RNA polymerase II subunit F
VGNC:44797
474512
Horse
RNA polymerase II subunit F
VGNC:21678
100054935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit F
Mouse
Rat
Dog
RNA polymerase II subunit F
Horse
RNA polymerase II subunit F
Publication Statistics
PubMed Score 23.70
PubMed score by year
PubTator Score 12.28
PubTator score by year