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Tbio
ARF3
ADP-ribosylation factor 3

Protein Summary
Description
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256682
  • ENSP00000256682
  • ENSG00000134287
  • ENST00000447318
  • ENSP00000395370
  • ENST00000541959
  • ENSP00000438510
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.9
transcription factor perturbation
0.84
cellular component
0.8
co-expressed gene
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.35   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.35   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
43.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
43.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99432
11842
Rat
Horse
ADP ribosylation factor 3
100051578
Anole lizard
ADP ribosylation factor 3
100562735
Xenopus
ADP ribosylation factor 3
XB-GENE-952628
100145191
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
ADP ribosylation factor 3
Anole lizard
ADP ribosylation factor 3
Xenopus
ADP ribosylation factor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P61204-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (242)
1 – 10 of 242
ARF5
Tbio
Family: Enzyme
Novelty: 0.02454098
p_int: 0.999934482
p_ni: 0.000065518
Score: 0.908
Data Source: BioPlex,STRINGDB
COPB1
Tbio
Novelty: 0.0078407
Score: 0.96
Data Source: STRINGDB
KIF23
Tbio
Novelty: 0.00719651
Score: 0.958
Data Source: STRINGDB
GBF1
Tbio
Novelty: 0.10901631
Score: 0.956
Data Source: STRINGDB
ARFGAP1
Tbio
Family: Enzyme
Novelty: 0.02654081
Score: 0.956
Data Source: STRINGDB
COPB2
Tbio
Novelty: 0.02705751
Score: 0.95
Data Source: STRINGDB
PI4KB
Tchem
Family: Kinase
Novelty: 0.00856875
Score: 0.944
Data Source: Reactome,STRINGDB
ARFGAP3
Tbio
Family: Enzyme
Novelty: 0.02542172
Score: 0.942
Data Source: STRINGDB
YKT6
Tbio
Novelty: 0.01591063
Score: 0.941
Data Source: STRINGDB
ARCN1
Tbio
Novelty: 0.06716916
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  192.35

PubMed score by year
PubTator Score  38.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer