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Tbio
ACTR1A
Alpha-centractin

Protein Summary
Description
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369905
  • ENSP00000358921
  • ENSG00000138107

Symbol
  • CTRN1
  • ARP1
  • Arp1A
  • CTRN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.92
interacting protein
0.8
transcription factor perturbation
0.8
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (357)
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.999980666
p_ni:  0.000019334
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999941174
p_ni:  0.000058826
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.999892346
p_ni:  0.000107654
Score:  0.985
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.99936814
p_ni:  0.00063186
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.996611013
p_ni:  0.003388987
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.99429513
p_ni:  0.00570487
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.988859226
p_ni:  0.011140775
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.976781778
p_ni:  0.023218223
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.972399563
p_ni:  0.000099797
p_wrong:  0.02750064
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.963986534
p_ni:  0.036013466
Score:  0.554
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1
85.6
4
3
2
1
78.6
2
2
0
1.1
75
leukocyte count
2
2
2
68.1
eosinophil count
2
2
2
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
85.6
2
1
78.6
0
1.1
75
leukocyte count
2
68.1
eosinophil count
2
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARP1 actin related protein 1 homolog A
VGNC:14557
466191
Macaque
ARP1 actin related protein 1 homolog A
713513
Mouse
MGI:1858964
54130
Rat
RGD:1307025
294010
Dog
ARP1 actin related protein 1 homolog A
VGNC:37552
403791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARP1 actin related protein 1 homolog A
Macaque
ARP1 actin related protein 1 homolog A
Mouse
Rat
Dog
ARP1 actin related protein 1 homolog A
Publication Statistics
PubMed Score 14.46
PubMed score by year
PubTator Score 47.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title