You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACTR1A
Alpha-centractin

Protein Summary
Description
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369905
  • ENSP00000358921
  • ENSG00000138107

Symbol
  • CTRN1
  • ARP1
  • Arp1A
  • CTRN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.92
interacting protein
0.8
transcription factor perturbation
0.8
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1
90.8
Eczema
1
1
0
1
57.4
1
1
0
1
57.4
insomnia measurement
2
1
0
1
56.6
platelet crit
1
1
1
34.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
90.8
Eczema
0
1
57.4
0
1
57.4
insomnia measurement
0
1
56.6
platelet crit
1
34.5
Pathways (34)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (357)
1 – 10 of 357
ACTR10
Tbio
Novelty: 0.11388846
p_int: 0.999980666
p_ni: 0.000019334
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty: 0.30624393
p_int: 0.999941174
p_ni: 0.000058826
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty: 0.10014723
p_int: 0.999892346
p_ni: 0.000107654
Score: 0.985
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
p_int: 0.99936814
p_ni: 0.00063186
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DCTN4
Tbio
Novelty: 0.10319227
p_int: 0.996611013
p_ni: 0.003388987
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty: 0.14551388
p_int: 0.99429513
p_ni: 0.00570487
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.988859226
p_ni: 0.011140775
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
p_int: 0.976781778
p_ni: 0.023218223
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCTN5
Tdark
Novelty: 0.19530162
p_int: 0.972399563
p_ni: 0.000099797
p_wrong: 0.02750064
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.963986534
p_ni: 0.036013466
Score: 0.554
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.46

PubMed score by year
PubTator Score  47.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer