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Tchem
ACTR2
Actin-related protein 2

Protein Summary
Description
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260641
  • ENSP00000260641
  • ENSG00000138071
  • ENST00000377982
  • ENSP00000367220

Symbol
  • ARP2
  • ARP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.96
molecular function
0.91
disease perturbation
0.87
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.89   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.89   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
talmapimod
Rendered image for talmapimod
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
2
1.1
80.2
self reported educational attainment
1
1
1
60.5
tonsillectomy risk measurement
1
1
0
1.1
52.7
heel bone mineral density
2
2
2
52.4
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
80.2
self reported educational attainment
1
60.5
tonsillectomy risk measurement
0
1.1
52.7
heel bone mineral density
2
52.4
0
1.1
21.5
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARP2 actin related protein 2 homolog
746973
Macaque
ARP2 actin related protein 2 homolog
697080
Mouse
MGI:1913963
66713
Rat
RGD:1310826
289820
Dog
ARP2 actin related protein 2 homolog
VGNC:37554
481396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARP2 actin related protein 2 homolog
Macaque
ARP2 actin related protein 2 homolog
Mouse
Rat
Dog
ARP2 actin related protein 2 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P61160-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (47)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (40)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (439)
1 – 10 of 439
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.99988571
p_ni:  0.00011429
Score:  0.984
Data Source:  BioPlex,STRINGDB
ARPC1A
Tbio
Novelty:  0.07577807
p_int:  0.997610987
p_ni:  0.002389013
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
p_int:  0.997003372
p_ni:  0.002996628
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC1B
Tbio
Novelty:  0.03873325
p_int:  0.996328509
p_ni:  0.003671491
Score:  0.999
Data Source:  BioPlex,STRINGDB
CHURC1
Tbio
Novelty:  0.05885372
p_int:  0.975948134
p_ni:  0.024051866
Data Source:  BioPlex
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.97525584
p_ni:  0.02474416
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC2
Tbio
Novelty:  0.02478791
Score:  0.999
Data Source:  STRINGDB
ARPC5L
Tdark
Novelty:  0.35566409
Score:  0.999
Data Source:  STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
Score:  0.999
Data Source:  STRINGDB
ARPC4
Tbio
Novelty:  0.04212335
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  138.89

PubMed score by year
PubTator Score  667.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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