Protein Summary
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This comp ...more
- ENST00000260641
- ENSP00000260641
- ENSG00000138071
- ENST00000377982
- ENSP00000367220
- ARP2
- ARP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.99 | ||
transcription factor perturbation | 0.96 | ||
molecular function | 0.91 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.31 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.31 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (499 Tissues)
none
JensenLab TISSUES
Circle Plot (2)
Anatomogram
root: immaterial entity (BFO:0000141)
root: material entity (BFO:0000040)
Coexpression Data
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
Protein-Protein Interactions (439)
1 – 10 of 439
ACTR3B
Novelty: 0.06033214
p_int: 0.99988571
p_ni: 0.00011429
Score: 0.984
Data Source: BioPlex,STRINGDB
ARPC1A
Novelty: 0.07577807
p_int: 0.997610987
p_ni: 0.002389013
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3
Novelty: 0.02112745
p_int: 0.997003372
p_ni: 0.002996628
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC1B
Novelty: 0.03873325
p_int: 0.996328509
p_ni: 0.003671491
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC3
Novelty: 0.02951522
p_int: 0.97525584
p_ni: 0.02474416
Score: 0.999
Data Source: BioPlex,STRINGDB
Predicted Interactions
Nearest Tclin Targets
Pathways (47)
Reactome (16)
KEGG (2)
PathwayCommons (10)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Items per page:
5
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHB-mediated forward signaling | ||||
Interacting Pathways
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (3)
Components (17)
Processes (20)
Items per page:
5
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (32)
1 – 10 of 32
lung adenocarcinoma
Expression Atlas, JensenLab Experiment TIGA
- Disease ID: DOID:3910
- Log 2 fold change: 1.374
- p-value: 9.09930320374624e-8
- Disease ID: DOID:3910
- Evidence: MeanRankScore = 43
- Confidence: 1.1
pancreatic ductal adenocarcinoma
Expression Atlas
- Disease ID: DOID:3498
- Log 2 fold change: 1.392
- p-value: 0.0077501936725345
Parkinson disease
Expression Atlas
- Disease ID: DOID:14330
- Log 2 fold change: -1.4
- p-value: 0.0172814559154072
psoriasis
Expression Atlas
- Disease ID: DOID:8893
- Log 2 fold change: 1.1
- p-value: 0.000457440655550035
Sjogren syndrome
Expression Atlas
- Disease ID: DOID:12894
- Log 2 fold change: 2
- p-value: 0.0000570319924218488
Alzheimer disease
Expression Atlas
- Disease ID: DOID:10652
- Log 2 fold change: -1.1
- p-value: 0.019363433660153
breast carcinoma
Expression Atlas
- Disease ID: DOID:3459
- Log 2 fold change: 1.1
- p-value: 0.00615753433403714
exocrine pancreatic carcinoma
Expression Atlas
- Disease ID: DOID:4905
- Log 2 fold change: -1.3
- p-value: 0.0131047951308072
IgA glomerulonephritis
eRAM
- Disease ID: DOID:2986
- Source: CTD_human
lymphoplasmacytic lymphoma
Expression Atlas
- Disease ID: DOID:0050747
- Log 2 fold change: 1.583
- p-value: 0.0105378419664392
Predicted Diseases
Disease Novelty (TIN-X)
none
root: disease (DOID:4)
GWAS Traits (19)
Items per page:
5
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
5 | 3 | 2 | 1.1 | 93.7 | |||||
self reported educational attainment | 3 | 2 | 3 | 84.4 | |||||
eosinophil count | 3 | 2 | 3 | 75.5 | |||||
myeloid white cell count | 1 | 1 | 1 | 71.2 | |||||
neutrophil count | 2 | 1 | 2 | 70.6 | |||||
none
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
---|---|---|---|
IDG Resources
Orthologs (18)
1 – 5 of 18
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ARP2 actin related protein 2 homolog | 746973 | ||||||
Macaque | ARP2 actin related protein 2 homolog | 697080 | ||||||
Mouse | MGI:1913963 | 66713 | ||||||
Rat | RGD:1310826 | 289820 | ||||||
Dog | ARP2 actin related protein 2 homolog | VGNC:37554 | 481396 | |||||
Publication Statistics
PubMed Score 156.31
PubMed score by year
none
PubTator Score 667.82
PubTator score by year
none
Publications (95)
Items per page:
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1 – 5 of 95
Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay.
Hao et al., Journal of virology, 2023-12-21
Abstract: (show)
Transition State of Arp2/3 Complex Activation by Actin-Bound Dimeric Nucleation-Promoting Factor.
Eeuwen et al., Proceedings of the National Academy of Sciences of the United States of America, 2023-08-15
Abstract: (show)
ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.
Sadhu et al., eLife, 2023-05-10
Abstract: (show)
A familial 2p14 microdeletion disrupting actin-related protein 2 and Ras-related protein Rab-1A genes with intellectual disability and language impairment.
Tabata et al., European journal of medical genetics, 2022-03
Abstract: (show)
Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma.
Zhang et al., The Journal of biological chemistry, 2020-04-17
Abstract: (show)