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Tbio
ACTR3
Actin-related protein 3

Protein Summary
Description
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263238
  • ENSP00000263238
  • ENSG00000115091

Symbol
  • ARP3
  • ARP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
interacting protein
0.98
transcription factor binding site profile
0.94
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.04   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.04   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (24)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (28)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (299)
1 – 10 of 299
ARPC1A
Tbio
Novelty: 0.10861673
p_int: 0.999524435
p_ni: 0.000475565
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC5
Tbio
Novelty: 0.08405086
p_int: 0.999021034
p_ni: 0.000978966
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR2
Tbio
Novelty: 0.01032806
p_int: 0.997003372
p_ni: 0.002996628
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3B
Tbio
Novelty: 0.09881697
p_int: 0.996287125
p_ni: 0.003712875
Score: 0.911
Data Source: BioPlex,STRINGDB
ARPC3
Tbio
Novelty: 0.0428612
p_int: 0.995471451
p_ni: 0.004528549
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC1B
Tbio
Novelty: 0.05202587
p_int: 0.991712451
p_ni: 0.008287549
Score: 0.999
Data Source: BioPlex,STRINGDB
CST1
Tbio
Novelty: 0.02481888
p_int: 0.989999487
p_ni: 0.008920251
p_wrong: 0.001080263
Data Source: BioPlex
CST4
Tbio
Novelty: 0.010423
p_int: 0.959561907
p_ni: 0.037895548
p_wrong: 0.002542545
Data Source: BioPlex
ARPC2
Tbio
Novelty: 0.04147436
p_int: 0.949399347
p_ni: 0.050600653
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC5L
Tdark
Novelty: 0.72650824
p_int: 0.896581186
p_ni: 0.103418814
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.04

PubMed score by year
PubTator Score  179.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer