You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAB14
Ras-related protein Rab-14

Protein Summary
Description
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373840
  • ENSP00000362946
  • ENSG00000119396

Symbol
  • FBP
  • RAB-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
interacting protein
0.98
transcription factor perturbation
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.13   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.13   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (220)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999980164
p_ni:  0.000019836
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.999880037
p_ni:  0.000119963
Data Source:  BioPlex
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.999626951
p_ni:  0.000373049
Score:  0.985
Data Source:  BioPlex,STRINGDB
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.981522269
p_ni:  0.018477391
p_wrong:  3.41e-7
Data Source:  BioPlex
TBC1D4
Tbio
Novelty:  0.00549202
Score:  0.975
Data Source:  STRINGDB
RUFY1
Tbio
Novelty:  0.16796947
Score:  0.963
Data Source:  Reactome,STRINGDB
SLC2A4
Tchem
Family:  Transporter
Novelty:  0.00033701
Score:  0.961
Data Source:  STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
Score:  0.96
Data Source:  STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
Score:  0.959
Data Source:  STRINGDB
EXOC6
Tbio
Novelty:  0.01886811
Score:  0.956
Data Source:  STRINGDB
Pathways (84)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
46.9
hemoglobin measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
46.9
hemoglobin measurement
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB14, member RAS oncogene family
VGNC:9194
744531
Mouse
MGI:1915615
68365
Rat
RGD:620881
94197
Dog
RAB14, member RAS oncogene family
VGNC:45254
474818
Horse
RAB14, member RAS oncogene family
VGNC:22089
100067611
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB14, member RAS oncogene family
Mouse
Rat
Dog
RAB14, member RAS oncogene family
Horse
RAB14, member RAS oncogene family
Publication Statistics
PubMed Score 57.13
PubMed score by year
PubTator Score 32.34
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title