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Tbio
RAB14
Ras-related protein Rab-14

Protein Summary
Description
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373840
  • ENSP00000362946
  • ENSG00000119396

Symbol
  • FBP
  • RAB-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
interacting protein
0.98
transcription factor perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.35   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.35   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (84)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Metabolism
Metabolism of lipids
Gene Ontology Terms (38)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (220)
1 – 10 of 220
GDI1
Tbio
Novelty: 0.02210681
p_int: 0.999980164
p_ni: 0.000019836
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
FIS1
Tbio
Novelty: 0.00552092
p_int: 0.999880037
p_ni: 0.000119963
Data Source: BioPlex
RAB2B
Tdark
Family: Enzyme
Novelty: 0.27592248
p_int: 0.999626951
p_ni: 0.000373049
Score: 0.985
Data Source: BioPlex,STRINGDB
TMEM159
Tdark
Novelty: 0.36363636
p_int: 0.981522269
p_ni: 0.018477391
p_wrong: 3.41e-7
Data Source: BioPlex
TBC1D4
Tbio
Novelty: 0.00751276
Score: 0.975
Data Source: STRINGDB
RUFY1
Tbio
Novelty: 0.22094603
Score: 0.963
Data Source: Reactome,STRINGDB
SLC2A4
Tbio
Family: Transporter
Novelty: 0.00043859
Score: 0.961
Data Source: STRINGDB
EXOC3
Tbio
Novelty: 0.01423005
Score: 0.96
Data Source: STRINGDB
YWHAG
Tbio
Novelty: 0.01155855
Score: 0.959
Data Source: STRINGDB
EXOC6
Tbio
Novelty: 0.02897817
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.35

PubMed score by year
PubTator Score  32.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer