UBE2N
Ubiquitin-conjugating enzyme E2 N
Protein Summary
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the ...more
- ENST00000318066
- ENSP00000316176
- ENSG00000177889
- BLU
- UBC13
- UbcH13
- HEL-S-71
- UbcH-ben
- UBCHBEN; UBC13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
interacting protein | 0.99 | ||
biological process | 0.98 | ||
molecular function | 0.98 | ||
kinase perturbation | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.1 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 341 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.1 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 341 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (13)
Protein-Protein Interactions (611)
Nearest Tclin Targets
Pathways (199)
Reactome (65)
KEGG (1)
PathwayCommons (14)
UniProt (1)
WikiPathways (118)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (6)
Components (10)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 2 | 2 | 82 | |||||
red blood cell distribution width | 2 | 2 | 2 | 76.7 | |||||
reticulocyte measurement | 3 | 2 | 3 | 66.6 | |||||
reticulocyte count | 3 | 2 | 3 | 58.9 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 2 | 82 | |||||
red blood cell distribution width | 2 | 76.7 | |||||
reticulocyte measurement | 3 | 66.6 | |||||
reticulocyte count | 3 | 58.9 | |||||
mean reticulocyte volume | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin conjugating enzyme E2 N | VGNC:5641 | 452125 | |||||
Macaque | ubiquitin conjugating enzyme E2 N | 715437 | ||||||
Mouse | MGI:1934835 | 93765 | ||||||
Rat | RGD:621096 | 116725 | ||||||
Horse | ubiquitin-conjugating enzyme E2 N | 102150222 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquitin conjugating enzyme E2 N | |||||
Macaque | ubiquitin conjugating enzyme E2 N | |||||
Mouse | ||||||
Rat | ||||||
Horse | ubiquitin-conjugating enzyme E2 N | |||||
Publication Statistics
PubMed Score 158.10
PubMed score by year
PubTator Score 91.75
PubTator score by year
Related Publications
Text Mined References (87)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
|---|