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Tbio
UBE2N
Ubiquitin-conjugating enzyme E2 N

Protein Summary
Description
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318066
  • ENSP00000316176
  • ENSG00000177889

Symbol
  • BLU
  • UBC13
  • UbcH13
  • HEL-S-71
  • UbcH-ben
  • UBCHBEN; UBC13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.99
biological process
0.98
molecular function
0.98
kinase perturbation
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.29   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.29   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
67.3
mean reticulocyte volume
1
1
1
26.3
platelet crit
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
67.3
mean reticulocyte volume
1
26.3
platelet crit
1
4.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 N
VGNC:5641
452125
Macaque
ubiquitin conjugating enzyme E2 N
715437
Mouse
MGI:1934835
93765
Rat
RGD:621096
116725
Horse
ubiquitin-conjugating enzyme E2 N
102150222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 N
Macaque
ubiquitin conjugating enzyme E2 N
Mouse
Rat
Horse
ubiquitin-conjugating enzyme E2 N
Protein Structure (26 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61088-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 26
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (199)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 65
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Antiviral mechanism by IFN-stimulated genes
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (611)
1 – 10 of 611
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.999
Data Source: Reactome,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.999
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.998
Data Source: Reactome,STRINGDB
UBE2V1
Tbio
Novelty: 0.01642178
Score: 0.998
Data Source: Reactome,STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.998
Data Source: STRINGDB
STUB1
Tbio
Family: Enzyme
Novelty: 0.00055102
Score: 0.998
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.998
Data Source: STRINGDB
ZNRF1
Tbio
Family: Enzyme
Novelty: 0.15739853
Score: 0.997
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.996
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00419724
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  153.29

PubMed score by year
PubTator Score  91.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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