Tchem UBE2M NEDD8-conjugating enzyme Ubc12

Protein Summary

Description

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P61081
• O76069
• Q8VC50

Gene Name

• UBE2M

Ensembl ID

• ENST00000253023
• ENSP00000253023
• ENSG00000130725

Symbol

• UBC12
• UBC12
• hUbc12
• UBC-RS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
molecular function	0.98
disease perturbation	0.79
hub protein	0.75
transcription factor binding site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.05   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.05   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

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1 – 1 of 1

CHEMBL4099097

UBE2MTchem

pKd : 6

Protein-Protein Interactions (403)

Explore Interacting Targets

1 – 10 of 403

• See Interactions on String-DB

DCUN1D1

Tchem

Novelty:  0.03122408

p_int:  0.99999941

p_ni:  2.9e-8

p_wrong:  5.61e-7

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

KCTD6

Tbio

Novelty:  0.43478298

p_int:  0.999990684

p_ni:  0.000009125

p_wrong:  1.91e-7

Score:  0.914

Data Source:  BioPlex,STRINGDB

KLHL42

Tdark

Novelty:  0.25822395

p_int:  0.999984949

p_ni:  0.000015051

Score:  0.908

Data Source:  BioPlex,STRINGDB

NAE1

Tchem

Novelty:  0.0283623

p_int:  0.999959033

p_ni:  0.000040967

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

UBA3

Tchem

Novelty:  0.03962261

p_int:  0.999938672

p_ni:  0.000061328

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

KLHL18

Tdark

Novelty:  0.52915213

p_int:  0.999485731

p_ni:  0.000514269

Score:  0.166

Data Source:  BioPlex,STRINGDB

RHOBTB1

Tbio

Novelty:  0.02152609

p_int:  0.997165525

p_ni:  0.000257322

p_wrong:  0.002577152

Score:  0.561

Data Source:  BioPlex,STRINGDB

KBTBD7

Tdark

Novelty:  0.4947466

p_int:  0.996397561

p_ni:  0.003602439

Score:  0.908

Data Source:  BioPlex,STRINGDB

COPS7A

Tbio

Novelty:  0.02159233

p_int:  0.995540719

p_ni:  0.004459281

Score:  0.772

Data Source:  BioPlex,STRINGDB

COPS2

Tbio

Novelty:  0.03509351

p_int:  0.992139229

p_ni:  0.007860771

Score:  0.583

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (22)

Reactome (18)

KEGG (1)

PathwayCommons (2)

UniProt (1)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	CLEC7A (Dectin-1) signaling	101 targets	R-HSA-5607764
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
CLEC7A (Dectin-1) signaling	101 targets	R-HSA-5607764
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (3)

Components (2)

Processes (4)

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1 – 3 of 3

GO Term	Evidence	Assigned by
NEDD8 transferase activity	Inferred from Direct Assay (IDA)	UniProtKB
ubiquitin-protein transferase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (10)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3	2	3		78.7
mathematical ability	EFO_0004875	3	2	3		64
mean reticulocyte volume	EFO_0010701	1	1	1		49.5
red blood cell distribution width	EFO_0005192	1	1	1		49.5
intelligence	EFO_0004337	1	1	0	6.2	38.2

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3		78.7
mathematical ability	EFO_0004875	3		64
mean reticulocyte volume	EFO_0010701	1		49.5
red blood cell distribution width	EFO_0005192	1		49.5
intelligence	EFO_0004337	0	6.2	38.2

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
ATP-binding
Complete proteome
Methylation
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation pathway

GWAS Trait Find Similar Targets

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cognitive function measurement
colorectal adenoma
colorectal cancer
heel bone mineral density
intelligence
mathematical ability
mean reticulocyte volume
puberty onset measurement
red blood cell distribution width
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

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growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	ubiquitin-conjugating enzyme E2M	MGI:108278	22192
Rat	ubiquitin-conjugating enzyme E2M	RGD:1307614	361509
Dog	ubiquitin conjugating enzyme E2 M	VGNC:48059	484221
Horse	ubiquitin conjugating enzyme E2 M	VGNC:24724	100064883
Cow	ubiquitin conjugating enzyme E2 M	VGNC:36589	613343

Species	Name	OMA	EggNOG	Inparanoid
Mouse	ubiquitin-conjugating enzyme E2M
Rat	ubiquitin-conjugating enzyme E2M
Dog	ubiquitin conjugating enzyme E2 M
Horse	ubiquitin conjugating enzyme E2 M
Cow	ubiquitin conjugating enzyme E2 M

Publication Statistics

PubMed Score 44.05

PubMed score by year

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PubTator Score 26.34

PubTator score by year

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Related Publications

Text Mined References (36)

GeneRif Annotations (12)

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PMID	Year	Title