UBE2M
NEDD8-conjugating enzyme Ubc12
Protein Summary
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
- ENST00000253023
- ENSP00000253023
- ENSG00000130725
- UBC12
- UBC12
- hUbc12
- UBC-RS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
molecular function | 0.98 | ||
disease perturbation | 0.79 | ||
hub protein | 0.75 | ||
transcription factor binding site profile | 0.7 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.47 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.47 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:108278 | 22192 | ||||||
Rat | RGD:1307614 | 361509 | ||||||
Dog | ubiquitin conjugating enzyme E2 M | VGNC:48059 | 484221 | |||||
Horse | ubiquitin conjugating enzyme E2 M | VGNC:24724 | 100064883 | |||||
Cow | ubiquitin conjugating enzyme E2 M | VGNC:36589 | 613343 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | ubiquitin conjugating enzyme E2 M | |||||
Horse | ubiquitin conjugating enzyme E2 M | |||||
Cow | ubiquitin conjugating enzyme E2 M | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (22)
Reactome (18)
KEGG (1)
PathwayCommons (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 18
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
Class I MHC mediated antigen processing & presentation | ||||
Gene Ontology Terms (9)
Functions (3)
Components (2)
Processes (4)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (403)
1 – 10 of 403
DCUN1D1
Novelty: 0.03122408
p_int: 0.99999941
p_ni: 2.9e-8
p_wrong: 5.61e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KCTD6
Novelty: 0.43478298
p_int: 0.999990684
p_ni: 0.000009125
p_wrong: 1.91e-7
Score: 0.914
Data Source: BioPlex,STRINGDB
KLHL42
Novelty: 0.25822395
p_int: 0.999984949
p_ni: 0.000015051
Score: 0.908
Data Source: BioPlex,STRINGDB
NAE1
Novelty: 0.0283623
p_int: 0.999959033
p_ni: 0.000040967
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
UBA3
Novelty: 0.03962261
p_int: 0.999938672
p_ni: 0.000061328
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KLHL18
Novelty: 0.52915213
p_int: 0.999485731
p_ni: 0.000514269
Score: 0.166
Data Source: BioPlex,STRINGDB
RHOBTB1
Novelty: 0.02152609
p_int: 0.997165525
p_ni: 0.000257322
p_wrong: 0.002577152
Score: 0.561
Data Source: BioPlex,STRINGDB
KBTBD7
Novelty: 0.4947466
p_int: 0.996397561
p_ni: 0.003602439
Score: 0.908
Data Source: BioPlex,STRINGDB
COPS7A
Novelty: 0.02159233
p_int: 0.995540719
p_ni: 0.004459281
Score: 0.772
Data Source: BioPlex,STRINGDB
COPS2
Novelty: 0.03509351
p_int: 0.992139229
p_ni: 0.007860771
Score: 0.583
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 42.47
PubMed score by year
PubTator Score 26.34
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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