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Tbio
UBE2M
NEDD8-conjugating enzyme Ubc12

Protein Summary
Description
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253023
  • ENSP00000253023
  • ENSG00000130725

Symbol
  • UBC12
  • UBC12
  • hUbc12
  • UBC-RS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.98
disease perturbation
0.79
hub protein
0.75
transcription factor binding site profile
0.7


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.47   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.47   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108278
22192
Rat
RGD:1307614
361509
Dog
ubiquitin conjugating enzyme E2 M
VGNC:48059
484221
Horse
ubiquitin conjugating enzyme E2 M
VGNC:24724
100064883
Cow
ubiquitin conjugating enzyme E2 M
VGNC:36589
613343
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 M
Horse
ubiquitin conjugating enzyme E2 M
Cow
ubiquitin conjugating enzyme E2 M
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61081-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Class I MHC mediated antigen processing & presentation
Protein-Protein Interactions (403)
1 – 10 of 403
DCUN1D1
Tbio
Novelty: 0.03122408
p_int: 0.99999941
p_ni: 2.9e-8
p_wrong: 5.61e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KCTD6
Tbio
Novelty: 0.43478298
p_int: 0.999990684
p_ni: 0.000009125
p_wrong: 1.91e-7
Score: 0.914
Data Source: BioPlex,STRINGDB
KLHL42
Tdark
Novelty: 0.25822395
p_int: 0.999984949
p_ni: 0.000015051
Score: 0.908
Data Source: BioPlex,STRINGDB
NAE1
Tchem
Novelty: 0.0283623
p_int: 0.999959033
p_ni: 0.000040967
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
UBA3
Tbio
Novelty: 0.03962261
p_int: 0.999938672
p_ni: 0.000061328
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KLHL18
Tdark
Novelty: 0.52915213
p_int: 0.999485731
p_ni: 0.000514269
Score: 0.166
Data Source: BioPlex,STRINGDB
RHOBTB1
Tbio
Novelty: 0.02152609
p_int: 0.997165525
p_ni: 0.000257322
p_wrong: 0.002577152
Score: 0.561
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.996397561
p_ni: 0.003602439
Score: 0.908
Data Source: BioPlex,STRINGDB
COPS7A
Tbio
Novelty: 0.02159233
p_int: 0.995540719
p_ni: 0.004459281
Score: 0.772
Data Source: BioPlex,STRINGDB
COPS2
Tbio
Novelty: 0.03509351
p_int: 0.992139229
p_ni: 0.007860771
Score: 0.583
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  42.47

PubMed score by year
PubTator Score  26.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer