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Tclin
CXCR4
C-X-C chemokine receptor type 4

Protein Summary
Description
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241393
  • ENSP00000241393
  • ENSG00000121966
  • ENST00000409817
  • ENSP00000386884

Symbol
  • FB22
  • HM89
  • LAP3
  • LCR1
  • NPYR
  • WHIM
  • CD184
  • LAP-3
  • LESTR
  • NPY3R
  • NPYRL
  • WHIMS
  • HSY3RR
  • NPYY3R
  • D2S201E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.99
transcription factor perturbation
0.99
gene perturbation
0.98
virus perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3719.22   (req: < 5)
Gene RIFs: 1300   (req: <= 3)
Antibodies: 1625   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3719.22   (req: >= 5)
Gene RIFs: 1300   (req: > 3)
Antibodies: 1625   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 187
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
plerixafor
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
84.4
monocyte percentage of leukocytes
2
3
3
72.3
1
1
0
1.7
32.9
granulocyte percentage of myeloid white cells
1
1
1
6.6
1
1
0
1.1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
84.4
monocyte percentage of leukocytes
3
72.3
0
1.7
32.9
granulocyte percentage of myeloid white cells
1
6.6
0
1.1
3.7
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Binding and entry of HIV virion
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Axon guidance
Binding and entry of HIV virion
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Developmental Biology
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (715)
1 – 10 of 715
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.985256071
p_ni: 0.014162968
p_wrong: 0.00058096
Score: 0.429
Data Source: BioPlex,STRINGDB
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.976330186
p_ni: 0.023661096
p_wrong: 0.000008718
Score: 0.925
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.975220023
p_ni: 0.024171683
p_wrong: 0.000608294
Data Source: BioPlex
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.964591613
p_ni: 0.035405092
p_wrong: 0.000003295
Score: 0.175
Data Source: BioPlex,STRINGDB
GCNT3
Tbio
Family: Enzyme
Novelty: 0.04356924
p_int: 0.949620862
p_ni: 0.050363611
p_wrong: 0.000015527
Score: 0.199
Data Source: BioPlex,STRINGDB
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.14959923
p_int: 0.934763216
p_ni: 0.065208587
p_wrong: 0.000028197
Data Source: BioPlex
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
p_int: 0.903224218
p_ni: 0.027225919
p_wrong: 0.069549863
Data Source: BioPlex
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.901005858
p_ni: 0.098972278
p_wrong: 0.000021863
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.883214014
p_ni: 0.029644905
p_wrong: 0.087141082
Data Source: BioPlex
IFNLR1
Tbio
Novelty: 0.01990628
p_int: 0.881346801
p_ni: 0.039915717
p_wrong: 0.078737482
Data Source: BioPlex
Publication Statistics
PubMed Score  3719.22

PubMed score by year
PubTator Score  3684.2

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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