You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAB10
Ras-related protein Rab-10

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264710
  • ENSP00000264710
  • ENSG00000084733
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
virus perturbation
0.92
cellular component
0.87
cell type or tissue
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.84   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.84   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (177)
1 – 10 of 177
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999938717
p_ni:  0.000061282
p_wrong:  1e-9
Score:  0.964
Data Source:  BioPlex,Reactome,STRINGDB
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.999483057
p_ni:  0.000516943
Score:  0.796
Data Source:  BioPlex,STRINGDB
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.954451231
p_ni:  0.045548769
Data Source:  BioPlex
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.982
Data Source:  STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
Score:  0.979
Data Source:  STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.974
Data Source:  Reactome,STRINGDB
DENND4C
Tbio
Novelty:  0.41302028
Score:  0.974
Data Source:  Reactome,STRINGDB
TBC1D4
Tbio
Novelty:  0.00549202
Score:  0.973
Data Source:  STRINGDB
EXOC6
Tbio
Novelty:  0.01886811
Score:  0.971
Data Source:  STRINGDB
EXOC4
Tbio
Novelty:  0.01636648
Score:  0.967
Data Source:  STRINGDB
Pathways (174)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (46)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
82.7
2
2
0
1.1
72.8
mean reticulocyte volume
1
1
1
48.5
2
1
2
28.1
apolipoprotein B measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
82.7
0
1.1
72.8
mean reticulocyte volume
1
48.5
2
28.1
apolipoprotein B measurement
1
17.8
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:105066
19325
Rat
RGD:620879
50993
Dog
RAB10, member RAS oncogene family
VGNC:45247
403958
Horse
RAB10, member RAS oncogene family
VGNC:22083
100055747
Cow
RAB10, member RAS oncogene family
VGNC:33613
783373
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RAB10, member RAS oncogene family
Horse
RAB10, member RAS oncogene family
Cow
RAB10, member RAS oncogene family
Publication Statistics
PubMed Score 106.84
PubMed score by year
PubTator Score 37.95
PubTator score by year