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Tbio
CKS1B
Cyclin-dependent kinases regulatory subunit 1

Protein Summary
Description
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308987
  • ENSP00000311083
  • ENSG00000173207

Symbol
  • CKS1
  • CKS1
  • ckshs1
  • PNAS-16
  • PNAS-18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.92
transcription factor perturbation
0.91
gene perturbation
0.9
small molecule perturbation
0.85


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.37   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.37   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC28 protein kinase regulatory subunit 1B
VGNC:1219
100608937
Mouse
MGI:1889208
54124
Horse
CDC28 protein kinase regulatory subunit 1B
VGNC:16566
100630884
Cow
CDC28 protein kinase regulatory subunit 1B
VGNC:27387
615827
Opossum
CDC28 protein kinase regulatory subunit 1B
100021385
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC28 protein kinase regulatory subunit 1B
Mouse
Horse
CDC28 protein kinase regulatory subunit 1B
Cow
CDC28 protein kinase regulatory subunit 1B
Opossum
CDC28 protein kinase regulatory subunit 1B
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Reactome
Cyclin E associated events during G1/S transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (319)
1 – 10 of 319
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
CDK3
Tchem
Family: Kinase
Novelty: 0.03380289
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.937
Data Source: BioPlex,STRINGDB
CCNB2
Tbio
Novelty: 0.00672914
p_int: 0.999999913
p_ni: 8.6e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
CDT1
Tbio
Novelty: 0.00398013
p_int: 0.999999671
p_ni: 3.29e-7
Score: 0.933
Data Source: BioPlex,STRINGDB
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
p_int: 0.999999598
p_ni: 4.02e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
p_int: 0.999999032
p_ni: 9.67e-7
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.999998686
p_ni: 0.000001314
Score: 0.869
Data Source: BioPlex,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999945137
p_ni: 0.000033945
p_wrong: 0.000020918
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  134.37

PubMed score by year
PubTator Score  35.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer