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Tbio
RAB5B
Ras-related protein Rab-5B

Protein Summary
Description
Protein transport. Probably involved in vesicular traffic (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360299
  • ENSP00000353444
  • ENSG00000111540
  • ENST00000448789
  • ENSP00000391319
  • ENST00000553116
  • ENSP00000450168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor binding site profile
0.84
cellular component
0.81
microRNA
0.75
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
86.5
childhood onset asthma
2
2
0
1.1
77.3
2
1
0
1.1
63.8
1
1
0
1.3
47.5
sum of eosinophil and basophil counts
1
1
1
29.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
86.5
childhood onset asthma
0
1.1
77.3
0
1.1
63.8
0
1.3
47.5
sum of eosinophil and basophil counts
1
29.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB5B, member RAS oncogene family
VGNC:10512
746457
Macaque
RAB5B, member RAS oncogene family
708347
Mouse
MGI:105938
19344
Rat
RGD:1306489
288779
Dog
RAB5B, member RAS oncogene family
VGNC:45292
474394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB5B, member RAS oncogene family
Macaque
RAB5B, member RAS oncogene family
Mouse
Rat
Dog
RAB5B, member RAS oncogene family
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Immune System
Innate Immune System
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (23)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (265)
1 – 10 of 265
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999999394
p_ni: 1.1e-8
p_wrong: 5.95e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
TGFA
Tbio
Novelty: 0.00216159
p_int: 0.999997016
p_ni: 0.000002983
Data Source: BioPlex
RAB2B
Tdark
Family: Enzyme
Novelty: 0.18567584
p_int: 0.999938851
p_ni: 0.000060279
p_wrong: 8.71e-7
Score: 0.97
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999727628
p_ni: 0.000272363
p_wrong: 1e-8
Data Source: BioPlex
PVR
Tbio
Novelty: 0.00215811
p_int: 0.999245225
p_ni: 0.000754772
p_wrong: 3e-9
Score: 0.194
Data Source: BioPlex,STRINGDB
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.998726373
p_ni: 0.000390226
p_wrong: 0.000883401
Data Source: BioPlex
PLEKHJ1
Tdark
Novelty: 1.44399298
p_int: 0.993150952
p_ni: 0.000495436
p_wrong: 0.006353613
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.992328579
p_ni: 0.00415412
p_wrong: 0.003517301
Data Source: BioPlex
POLE3
Tbio
Family: Enzyme
Novelty: 0.09657513
p_int: 0.97842699
p_ni: 0.000461586
p_wrong: 0.021111424
Data Source: BioPlex
FIS1
Tbio
Novelty: 0.0033607
p_int: 0.977778364
p_ni: 0.000427728
p_wrong: 0.021793908
Data Source: BioPlex
Publication Statistics
PubMed Score  31.44

PubMed score by year
PubTator Score  21.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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