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Tchem
RAB2A
Ras-related protein Rab-2A

Protein Summary
Description
Required for protein transport from the endoplasmic reticulum to the Golgi complex. The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262646
  • ENSP00000262646
  • ENSG00000104388
  • ENST00000531289
  • ENSP00000431846

Symbol
  • RAB2
  • LHX
  • RAB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
virus perturbation
0.98
interacting protein
0.96
kinase perturbation
0.95
molecular function
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.73   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.73   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
73.3
monocyte count
1
1
1
71.9
aspartate aminotransferase measurement
1
1
0
8.1
65.3
lymphocyte count
1
1
1
64
testosterone measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
73.3
monocyte count
1
71.9
aspartate aminotransferase measurement
0
8.1
65.3
lymphocyte count
1
64
testosterone measurement
1
56.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB2A, member RAS oncogene family
VGNC:7597
464197
Macaque
RAB2A, member RAS oncogene family
699383
Mouse
MGI:1928750
59021
Rat
RGD:68323
65158
Dog
RAB2A, member RAS oncogene family
VGNC:45271
404009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB2A, member RAS oncogene family
Macaque
RAB2A, member RAS oncogene family
Mouse
Rat
Dog
RAB2A, member RAS oncogene family
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61019-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Golgi Cisternae Pericentriolar Stack Reorganization
Reactome
M Phase
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Golgi Cisternae Pericentriolar Stack Reorganization
M Phase
Metabolism of proteins
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (179)
1 – 10 of 179
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.999999485
p_ni:  5.14e-7
p_wrong:  1e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
FAM71F2
Tdark
Novelty:  0.56916996
p_int:  0.997998327
p_ni:  0.002001673
Score:  0.877
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.970461454
p_ni:  0.029538545
Data Source:  BioPlex
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.960202947
p_ni:  0.039797053
Score:  0.242
Data Source:  BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.796849825
p_ni:  0.203150162
p_wrong:  1.4e-8
Score:  0.192
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.791853404
p_ni:  0.208146596
Data Source:  BioPlex
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.756253771
p_ni:  0.243746225
p_wrong:  4e-9
Score:  0.617
Data Source:  BioPlex,STRINGDB
BLZF1
Tbio
Novelty:  0.04344183
Score:  0.993
Data Source:  Reactome,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
Score:  0.99
Data Source:  STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.99
Data Source:  STRINGDB
Publication Statistics
PubMed Score  160.73

PubMed score by year
PubTator Score  60.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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