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Tbio
RAB4B
Ras-related protein Rab-4B

Protein Summary
Description
Protein transport. Probably involved in vesicular traffic (By similarity). RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357052
  • ENSP00000349560
  • ENSG00000167578
  • ENST00000594800
  • ENSP00000470246
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
molecular function
0.91
disease perturbation
0.79
cell type or tissue
0.72
transcription factor binding site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
53.3
hematocrit
1
1
1
25.4
hemoglobin measurement
1
1
1
21.4
eosinophil percentage of leukocytes
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
53.3
hematocrit
1
25.4
hemoglobin measurement
1
21.4
eosinophil percentage of leukocytes
1
21
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:105071
19342
Rat
RGD:620931
50866
Dog
RAB4B, member RAS oncogene family
VGNC:53756
403956
Horse
RAB4B, member RAS oncogene family
100064830
Pig
RAB4B, member RAS oncogene family
100523381
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RAB4B, member RAS oncogene family
Horse
RAB4B, member RAS oncogene family
Pig
RAB4B, member RAS oncogene family
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61018-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MET receptor recycling
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
MET receptor recycling
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (118)
1 – 10 of 118
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999999371
p_wrong: 6.29e-7
Score: 0.37
Data Source: BioPlex,STRINGDB
RAB7A
Tbio
Family: Enzyme
Novelty: 0.00192702
Score: 0.95
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.946
Data Source: STRINGDB
RAB34
Tbio
Novelty: 0.03645677
Score: 0.93
Data Source: STRINGDB
RAB34
Tbio
Family: Enzyme
Novelty: 0.03645677
Score: 0.93
Data Source: STRINGDB
RAB6A
Tbio
Family: Enzyme
Novelty: 0.00546034
Score: 0.928
Data Source: STRINGDB
RAB1B
Tbio
Family: Enzyme
Novelty: 0.02156819
Score: 0.928
Data Source: STRINGDB
RAB33A
Tbio
Family: Enzyme
Novelty: 0.11617001
Score: 0.928
Data Source: STRINGDB
RAB36
Tbio
Family: Enzyme
Novelty: 0.14109545
Score: 0.928
Data Source: STRINGDB
RAB33B
Tbio
Family: Enzyme
Novelty: 0.06381712
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.58

PubMed score by year
PubTator Score  5.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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