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Tbio
SRP54
Signal recognition particle 54 kDa protein

Protein Summary
Description
Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216774
  • ENSP00000216774
  • ENSG00000100883
  • ENST00000546080
  • ENSP00000440629
  • ENST00000556994
  • ENSP00000451818
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.94
protein domain
0.92
disease perturbation
0.9
cellular component
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (350)
1 – 10 of 350
SRP68
Tbio
Novelty: 0.0719445
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP9
Tbio
Novelty: 0.02725451
p_int: 0.999999932
p_ni: 6.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00100906
p_int: 0.995423226
p_ni: 0.004576774
Score: 0.433
Data Source: BioPlex,STRINGDB
GIMAP8
Tbio
Family: Enzyme
Novelty: 0.06741573
p_int: 0.993692152
p_ni: 0.006307848
Score: 0.806
Data Source: BioPlex,STRINGDB
CCDC102B
Tdark
Novelty: 0.44776119
p_int: 0.927033438
p_ni: 0.072966561
Data Source: BioPlex
DUSP22
Tbio
Family: Enzyme
Novelty: 0.02012116
p_int: 0.872135194
p_ni: 0.127864804
p_wrong: 2e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
CFAP47
Tdark
p_int: 0.835658935
p_ni: 0.164340592
p_wrong: 4.73e-7
Data Source: BioPlex
RLN1
Tbio
Novelty: 0.05712331
p_int: 0.758097759
p_ni: 0.241898425
p_wrong: 0.000003816
Data Source: BioPlex
MRPS11
Tdark
Novelty: 0.64495732
p_int: 0.756129799
p_ni: 0.243870199
p_wrong: 2e-9
Score: 0.848
Data Source: BioPlex,STRINGDB
SRP72
Tbio
Novelty: 0.03722414
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  150.62

PubMed score by year
PubTator Score  82.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer