Tbio SRP54 Signal recognition particle 54 kDa protein

Protein Summary

Description

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Uniprot Accession IDs

• P61011
• B2R759
• B4DUW6
• P13624
• SRP54

Gene Name

• SRP54

Ensembl ID

• ENST00000216774
• ENSP00000216774
• ENSG00000100883
• ENST00000546080
• ENSP00000440629
• ENST00000556994
• ENSP00000451818

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
interacting protein	0.94
protein domain	0.92
disease perturbation	0.9
cellular component	0.82

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Signal Recognition Particle 54 Kda Protein

Protein / Enzyme Modulator / G-protein / Signal Recognition Particle 54 Kda Protein

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Signal Recognition Particle 54 Kda Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.47   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.47   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0