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Tbio
RAB8A
Ras-related protein Rab-8A

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Plays an important role in ciliogenesis (PubMed:21844891). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300935
  • ENSP00000300935
  • ENSG00000167461
  • ENST00000586682
  • ENSP00000467501

Symbol
  • MEL
  • RAB8
  • MEL
  • RAB8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.99
virus perturbation
0.99
disease perturbation
0.97
interacting protein
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.18   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.18   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
76.7
mean corpuscular hemoglobin concentration
1
1
1
61.2
mean corpuscular hemoglobin
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
76.7
mean corpuscular hemoglobin concentration
1
61.2
mean corpuscular hemoglobin
1
27.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB8A, member RAS oncogene family
VGNC:7571
468760
Macaque
RAB8A, member RAS oncogene family
100423251
Mouse
MGI:96960
17274
Rat
RGD:621144
117103
Dog
RAB8A, member RAS oncogene family
VGNC:45295
403773
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB8A, member RAS oncogene family
Macaque
RAB8A, member RAS oncogene family
Mouse
Rat
Dog
RAB8A, member RAS oncogene family
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61006-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (120)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Cell Cycle
Cell Cycle, Mitotic
Cilium Assembly
Gene Ontology Terms (46)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (360)
1 – 10 of 360
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.999999999
p_ni: 1e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999999788
p_ni: 2.12e-7
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.999999186
p_ni: 8.14e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
RAB1A
Tbio
Family: Enzyme
Novelty: 0.00307527
p_int: 0.999385637
p_ni: 0.00061435
p_wrong: 1.3e-8
Score: 0.983
Data Source: BioPlex,STRINGDB
SRPRB
Tbio
Novelty: 0.04735362
p_int: 0.996649295
p_ni: 0.003350685
p_wrong: 2e-8
Data Source: BioPlex
RPH3A
Tbio
Family: Epigenetic
Novelty: 0.01321524
p_int: 0.992442008
p_ni: 0.007557987
p_wrong: 5e-9
Score: 0.796
Data Source: BioPlex,STRINGDB
RAB3IL1
Tbio
Novelty: 0.0167537
p_int: 0.971654395
p_ni: 0.02832901
p_wrong: 0.000016594
Score: 0.977
Data Source: BioPlex,STRINGDB
SLC1A1
Tchem
Family: Transporter
Novelty: 0.00218479
p_int: 0.8213597
p_ni: 0.178639363
p_wrong: 9.37e-7
Score: 0.207
Data Source: BioPlex,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.995
Data Source: Reactome,STRINGDB
RAB3IP
Tbio
Novelty: 0.04046982
Score: 0.993
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  185.18

PubMed score by year
PubTator Score  98.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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