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Tchem
CDC42
Cell division control protein 42 homolog

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migratio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315554
  • ENSP00000314458
  • ENSG00000070831
  • ENST00000344548
  • ENSP00000341072
  • ENST00000400259
  • ENSP00000383118

Symbol
  • TKS
  • G25K
  • CDC42Hs
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
0.99
pathway
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3326.22   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 475   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3326.22   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 475   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 64
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0