Protein Summary
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]
- ENST00000368809
- ENSP00000357799
- ENSG00000197747
- ENST00000368811
- ENSP00000357801
- ANX2LG
- CAL1L
- CLP11
- 42C
- P11
- p10
- GP11
- ANX2L
- CAL1L
- CLP11
- Ca[1]
- ANX2LG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
kinase perturbation | 0.97 | ||
gene perturbation | 0.85 | ||
PubMedID | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.6 (req: < 5)
Gene RIFs: 90 (req: <= 3)
Antibodies: 465 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.6 (req: >= 5)
Gene RIFs: 90 (req: > 3)
Antibodies: 465 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0