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Tbio
P60896
26S proteasome complex subunit SEM1

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248566
  • ENSP00000248566
  • ENSG00000127922

Symbol
  • C7orf76
  • DSS1
  • SHFDG1
  • SHFM1
  • ECD
  • DSS1
  • SHFD1
  • SHFM1
  • SHSF1
  • Shfdg1
  • C7orf76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.61   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.61   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (233)
PSMD3
Tbio
Family:  Enzyme
Novelty:  0.03106272
Score:  0.981
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.975
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.972
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.964
Data Source:  STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
Score:  0.96
Data Source:  STRINGDB
PSMD8
Tbio
Family:  Enzyme
Novelty:  0.03053455
Score:  0.959
Data Source:  STRINGDB
PSMD14
Tchem
Family:  Enzyme
Novelty:  0.01019285
Score:  0.958
Data Source:  STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
Score:  0.956
Data Source:  STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
Score:  0.956
Data Source:  STRINGDB
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (152)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
20
99.1
heel bone mineral density
3
7
20
99.1
bone density
5
8
20
96.5
bone density
5
8
20
96.5
femoral neck bone mineral density
2
2
4
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
20
99.1
heel bone mineral density
20
99.1
bone density
20
96.5
bone density
20
96.5
femoral neck bone mineral density
4
92.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEM1, 26S proteasome complex subunit
747549
Mouse
MGI:109238
20422
Cow
26S proteasome complex subunit DSS1
101907965
Pig
SEM1, 26S proteasome complex subunit
100524330
Platypus
SEM1, 26S proteasome complex subunit
100093442
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEM1, 26S proteasome complex subunit
Mouse
Cow
26S proteasome complex subunit DSS1
Pig
SEM1, 26S proteasome complex subunit
Platypus
SEM1, 26S proteasome complex subunit
Publication Statistics
PubMed Score 99.61
PubMed score by year
PubTator Score 177.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title