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Tbio
PRPS1
Ribose-phosphate pyrophosphokinase 1

Protein Summary
Description
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372435
  • ENSP00000361512
  • ENSG00000147224

Symbol
  • ARTS
  • DFN2
  • PRSI
  • CMTX5
  • DFNX1
  • PRS-I
  • PPRibP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
disease perturbation
0.93
transcription factor perturbation
0.88
PubMedID
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.91   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.91   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl pyrophosphate synthetase 1
VGNC:13524
465800
Macaque
phosphoribosyl pyrophosphate synthetase 1
702529
Mouse
MGI:97775
19139
Mouse
MGI:3779453
328099
Rat
RGD:61955
29562
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoribosyl pyrophosphate synthetase 1
Macaque
phosphoribosyl pyrophosphate synthetase 1
Mouse
Mouse
Rat
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P60891-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
5-Phosphoribose 1-diphosphate biosynthesis (R-HSA-73843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
5-Phosphoribose 1-diphosphate biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
5-Phosphoribose 1-diphosphate biosynthesis
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
PRPSAP2
Tbio
Family: Enzyme
Novelty: 0.12017454
p_int: 1
Score: 0.956
Data Source: BioPlex,STRINGDB
PRPS2
Tbio
Family: Kinase
Novelty: 0.02472415
p_int: 0.999999997
p_ni: 3e-9
Score: 0.973
Data Source: BioPlex,STRINGDB
PRPSAP1
Tbio
Family: Enzyme
Novelty: 0.08377292
p_int: 0.999999663
p_ni: 3.37e-7
Score: 0.948
Data Source: BioPlex,STRINGDB
PRPS1L1
Tdark
Family: Kinase
Novelty: 0.02527534
p_int: 0.999909084
p_ni: 0.000090915
p_wrong: 1e-9
Score: 0.964
Data Source: BioPlex,STRINGDB
NFRKB
Tbio
Novelty: 0.13445983
p_int: 0.998081512
p_ni: 0.001918488
Score: 0.281
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.993573381
p_ni: 0.006426618
p_wrong: 1e-9
Data Source: BioPlex
NDUFB9
Tclin
Family: Enzyme
Novelty: 0.00715628
p_int: 0.992272774
p_ni: 0.007663283
p_wrong: 0.000063942
Data Source: BioPlex
BRMS1
Tbio
Novelty: 0.01689792
p_int: 0.989927412
p_ni: 0.004853077
p_wrong: 0.005219511
Score: 0.177
Data Source: BioPlex,STRINGDB
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.989559584
p_ni: 0.010440416
Score: 0.546
Data Source: BioPlex,STRINGDB
CXXC1
Tbio
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.989039504
p_ni: 0.010954369
p_wrong: 0.000006127
Data Source: BioPlex
Publication Statistics
PubMed Score  88.91

PubMed score by year
PubTator Score  69.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer