Tclin SNAP25 Synaptosomal-associated protein 25

Protein Summary

Description

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P60880
• B2RAU4
• D3DW16
• D3DW17
• P13795
• P36974
• P70557
• P70558
• Q53EM2
• Q5U0B5
• Q8IXK3
• Q96FM2
• Q9BR45
• SNAP-25

Gene Name

• SNAP25

Ensembl ID

• ENST00000254976
• ENSP00000254976
• ENSG00000132639
• ENST00000304886
• ENSP00000307341

Symbol

• SNAP
• SUP
• RIC4
• SEC9
• SNAP
• CMS18
• RIC-4
• SNAP-25
• bA416N4.2
• dJ1068F16.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
phenotype	0.9
cellular component	0.88
biological process	0.79
transcription factor	0.78

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Synaptosomal-associated Protein 25

DTO Classes

Protein / Transporter / Snare Protein / Synaptosomal-associated Protein 25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 764.01   (req: < 5)

Gene RIFs: 152   (req: <= 3)

Antibodies: 1092   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 764.01   (req: >= 5)

Gene RIFs: 152   (req: > 3)

Antibodies: 1092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2