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Tbio
RPS20
40S ribosomal protein S20

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000009589
  • ENSP00000009589
  • ENSG00000008988
  • ENST00000519807
  • ENSP00000429374
  • ENST00000521262
  • ENSP00000427788
  • ENST00000618656
  • ENSP00000478703

Symbol
  • S20
  • uS10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
virus perturbation
0.96
transcription factor binding site profile
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (605)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.96247966
p_ni:  0.03752034
Score:  0.278
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.767171789
p_ni:  0.232828211
Score:  0.228
Data Source:  BioPlex,STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.999
Data Source:  STRINGDB
RPS3
Tbio
Novelty:  0.003106
Score:  0.999
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPS2
Tbio
Novelty:  0.00412313
Score:  0.999
Data Source:  STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
64
BMI-adjusted hip circumference
2
2
2
34.9
1
1
0
1.2
15.8
reticulocyte count
2
1
2
4.7
appendicular lean mass
1
1
1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
64
BMI-adjusted hip circumference
2
34.9
0
1.2
15.8
reticulocyte count
2
4.7
appendicular lean mass
1
3.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S20
VGNC:802
464184
Mouse
MGI:1914677
67427
Dog
ribosomal protein S20
477887
Horse
ribosomal protein S20
VGNC:22551
100053081
Cow
ribosomal protein S20
VGNC:34133
513222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S20
Mouse
Dog
ribosomal protein S20
Horse
ribosomal protein S20
Cow
ribosomal protein S20
Publication Statistics
PubMed Score 88.32
PubMed score by year
PubTator Score 76.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title