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Tchem
EIF4A1
Eukaryotic initiation factor 4A-I

Protein Summary
Description
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293831
  • ENSP00000293831
  • ENSG00000161960
  • ENST00000577269
  • ENSP00000463486

Symbol
  • DDX2A
  • EIF4A
  • DDX2A
  • EIF4A
  • EIF-4A
  • eIF4A-I
  • eIF-4A-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.98
disease perturbation
0.97
transcription factor perturbation
0.97
co-expressed gene
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.99   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.99   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (424)
IBTK
Tbio
Family:  Enzyme
Novelty:  0.03448246
p_int:  1
Score:  0.518
Data Source:  BioPlex,STRINGDB
EIF4G3
Tbio
Novelty:  0.03002723
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PDCD4
Tchem
Novelty:  0.00213303
p_int:  0.999999893
p_ni:  8.9e-8
p_wrong:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF4G2
Tbio
Novelty:  0.01424739
p_int:  0.999999537
p_ni:  4.61e-7
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
p_int:  0.999999309
p_ni:  6.91e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EIF4A2
Tbio
Novelty:  0.00298045
p_int:  0.999965491
p_ni:  0.000034509
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
p_int:  0.999265331
p_ni:  0.000734669
Score:  0.258
Data Source:  BioPlex,STRINGDB
EIF3H
Tbio
Novelty:  0.02564681
p_int:  0.998684468
p_ni:  0.001315532
Score:  0.991
Data Source:  BioPlex,STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
p_int:  0.994918898
p_ni:  0.005081102
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EIF4A3
Tchem
Novelty:  0.00981496
p_int:  0.993032224
p_ni:  0.006967776
Score:  0.951
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cap-dependent Translation Initiation
Reactome
Cytokine Signaling in Immune system
Reactome
Deadenylation of mRNA
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Antiviral mechanism by IFN-stimulated genes
Cap-dependent Translation Initiation
Cytokine Signaling in Immune system
Deadenylation of mRNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (64)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
10
29
40
100
sex hormone-binding globulin measurement
8
8
21
99.7
serum non-albumin protein measurement
3
9
11
99.2
blood protein measurement
2
7
7
97.6
hormone measurement
2
3
1
57
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
40
100
sex hormone-binding globulin measurement
21
99.7
serum non-albumin protein measurement
11
99.2
blood protein measurement
7
97.6
hormone measurement
1
57
94.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A1
VGNC:12107
748995
Macaque
eukaryotic translation initiation factor 4A1
106993879
Mouse
MGI:95303
13681
Rat
RGD:735141
287436
Dog
eukaryotic translation initiation factor 4A1
100688577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A1
Macaque
eukaryotic translation initiation factor 4A1
Mouse
Rat
Dog
eukaryotic translation initiation factor 4A1
Publication Statistics
PubMed Score 347.99
PubMed score by year
PubTator Score 149.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title