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Tchem
EIF4A1
Eukaryotic initiation factor 4A-I

Protein Summary
Description
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293831
  • ENSP00000293831
  • ENSG00000161960
  • ENST00000577269
  • ENSP00000463486

Symbol
  • DDX2A
  • EIF4A
  • DDX2A
  • EIF4A
  • EIF-4A
  • eIF4A-I
  • eIF-4A-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.98
disease perturbation
0.97
transcription factor perturbation
0.97
co-expressed gene
0.95


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.66   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.66   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A1
VGNC:12107
748995
Macaque
eukaryotic translation initiation factor 4A1
106993879
Mouse
MGI:95303
13681
Rat
RGD:735141
287436
Dog
eukaryotic translation initiation factor 4A1
100688577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A1
Macaque
eukaryotic translation initiation factor 4A1
Mouse
Rat
Dog
eukaryotic translation initiation factor 4A1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P60842-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cap-dependent Translation Initiation
Reactome
Cytokine Signaling in Immune system
Reactome
Deadenylation of mRNA
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Antiviral mechanism by IFN-stimulated genes
Cap-dependent Translation Initiation
Cytokine Signaling in Immune system
Deadenylation of mRNA
Gene Ontology Terms (16)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (424)
1 – 10 of 424
IBTK
Tbio
Family: Enzyme
Novelty: 0.03448246
p_int: 1
Score: 0.518
Data Source: BioPlex,STRINGDB
EIF4G3
Tbio
Novelty: 0.03002723
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PDCD4
Tchem
Novelty: 0.00213303
p_int: 0.999999893
p_ni: 8.9e-8
p_wrong: 1.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF4G2
Tbio
Novelty: 0.01424739
p_int: 0.999999537
p_ni: 4.61e-7
p_wrong: 2e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
p_int: 0.999999309
p_ni: 6.91e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4A2
Tbio
Novelty: 0.00298045
p_int: 0.999965491
p_ni: 0.000034509
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
IBA57
Tbio
Family: Enzyme
Novelty: 0.06327415
p_int: 0.999265331
p_ni: 0.000734669
Score: 0.258
Data Source: BioPlex,STRINGDB
EIF3H
Tbio
Novelty: 0.02564681
p_int: 0.998684468
p_ni: 0.001315532
Score: 0.991
Data Source: BioPlex,STRINGDB
EIF4E
Tchem
Novelty: 0.00072182
p_int: 0.994918898
p_ni: 0.005081102
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4A3
Tbio
Novelty: 0.00981496
p_int: 0.993032224
p_ni: 0.006967776
Score: 0.951
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  337.66

PubMed score by year
PubTator Score  149.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer