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Tbio
UBE2G2
Ubiquitin-conjugating enzyme E2 G2

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330942
  • ENSP00000331384
  • ENSG00000184787
  • ENST00000345496
  • ENSP00000338348

Symbol
  • UBC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
virus perturbation
0.97
transcription factor binding site profile
0.91
histone modification site profile
0.84
transcription factor
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.27   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.27   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (326)
1 – 10 of 326
AMFR
Tbio
Family: Enzyme
Novelty: 0.00533547
Score: 0.997
Data Source: STRINGDB
UBE2J2
Tbio
Novelty: 0.2367348
Score: 0.993
Data Source: STRINGDB
MARCH6
Tbio
Family: Enzyme
Novelty: 0.01818691
Score: 0.99
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00419724
Score: 0.98
Data Source: STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.973
Data Source: STRINGDB
UBA6
Tchem
Novelty: 0.05213412
Score: 0.971
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.967
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.962
Data Source: STRINGDB
UBA7
Tbio
Novelty: 0.01923008
Score: 0.96
Data Source: STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.03433452
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.27

PubMed score by year
PubTator Score  33.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer