Tchem IL2 Interleukin-2

Protein Summary

Description

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P60568
• P01585
• IL-2

Gene Name

• IL2

Ensembl ID

• ENST00000226730
• ENSP00000226730
• ENSG00000109471

Symbol

• IL-2
• TCGF
• lymphokine

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
disease	0.87
molecular function	0.79

Protein Classes

DTO Classes

Interleukin-27 Subunit Beta / Interleukin-27 Receptor Subunit Alpha / Interleukin-23 Receptor / Interleukin-23 Subunit Alpha / Interleukin-22 Receptor Subunit Alpha-2 / Interleukin-20 Receptor Subunit Alpha / Interleukin-22 Receptor Subunit Alpha-1 / Interleukin-20 Receptor Subunit Beta / Interleukin-2 Receptor Subunit Beta / Interleukin-21 Receptor / Interleukin-2 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33373.95   (req: < 5)

Gene RIFs: 573   (req: <= 3)

Antibodies: 1832   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33373.95   (req: >= 5)

Gene RIFs: 573   (req: > 3)

Antibodies: 1832   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0