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Tchem
IL2
Interleukin-2

Protein Summary
Description
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226730
  • ENSP00000226730
  • ENSG00000109471

Symbol
  • IL-2
  • TCGF
  • lymphokine
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease
0.87
molecular function
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31579.41   (req: < 5)
Gene RIFs: 488   (req: <= 3)
Antibodies: 1832   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31579.41   (req: >= 5)
Gene RIFs: 488   (req: > 3)
Antibodies: 1832   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
91.1
3
2
1
1.5
87.1
4
3
2
1.1
79.8
eosinophil count
1
1
1
54.2
2
2
0
1.3
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.1
1
1.5
87.1
2
1.1
79.8
eosinophil count
1
54.2
0
1.3
51.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 2
VGNC:617
461472
Macaque
interleukin 2
708017
Mouse
MGI:96548
16183
Rat
RGD:620047
116562
Dog
interleukin 2
VGNC:41963
403989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 2
Macaque
interleukin 2
Mouse
Rat
Dog
interleukin 2
Protein Data Bank (24)
1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (71)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (48)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (762)
1 – 10 of 762
IL17A
Tclin
Novelty: 0.00011583
p_int: 0.999999999
p_ni: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
IL2RA
Tclin
Novelty: 0.0007607
Score: 0.999
Data Source: Reactome,STRINGDB
IL2RG
Tclin
Novelty: 0.00108272
Score: 0.997
Data Source: Reactome,STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00017205
Score: 0.997
Data Source: STRINGDB
IL2RB
Tclin
Novelty: 0.0050905
Score: 0.996
Data Source: Reactome,STRINGDB
IL5
Tclin
Novelty: 0.0001684
Score: 0.995
Data Source: STRINGDB
CSF2
Tbio
Novelty: 0.00010437
Score: 0.994
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.991
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.991
Data Source: STRINGDB
IL3
Tbio
Novelty: 0.0002336
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  31579.41

PubMed score by year
PubTator Score  17629.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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