Tbio GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2

Protein Summary

Description

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Uniprot Accession IDs

• P60520
• O08765
• Q6FG91
• Q9DCP8
• Q9UQF7

Gene Name

• GABARAPL2

Ensembl ID

• ENST00000037243
• ENSP00000037243
• ENSG00000034713

Symbol

• FLC3A
• GEF2
• ATG8
• GEF2
• ATG8C
• GEF-2
• GATE16
• GATE-16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	0.92
disease perturbation	0.87
transcription factor perturbation	0.84
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Gamma-aminobutyric Acid Receptor-associated Protein-like 2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Gamma-aminobutyric Acid Receptor-associated Protein-like 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.38   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 515   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.38   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0