You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GABARAPL2
Gamma-aminobutyric acid receptor-associated protein-like 2

Protein Summary
Description
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000037243
  • ENSP00000037243
  • ENSG00000034713

Symbol
  • FLC3A
  • GEF2
  • ATG8
  • GEF2
  • ATG8C
  • GEF-2
  • GATE16
  • GATE-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
0.92
disease perturbation
0.87
transcription factor perturbation
0.84
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.54   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 515   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.54   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
1
1
0
1.1
38.8
Diarrhea
1
1
0
4.2
33.1
response to darapladib
1
1
0
4.2
33.1
age at first sexual intercourse measurement
1
1
1
28.1
smoking initiation
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
0
1.1
38.8
Diarrhea
0
4.2
33.1
response to darapladib
0
4.2
33.1
age at first sexual intercourse measurement
1
28.1
smoking initiation
1
26.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GABA type A receptor associated protein like 2
VGNC:9037
454251
Mouse
MGI:1890602
93739
Rat
RGD:620510
64670
Dog
GABA type A receptor associated protein like 2
VGNC:41047
479646
Horse
GABA type A receptor associated protein like 2
VGNC:51190
100055295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GABA type A receptor associated protein like 2
Mouse
Rat
Dog
GABA type A receptor associated protein like 2
Horse
GABA type A receptor associated protein like 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P60520-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Membrane Trafficking
Rab regulation of trafficking
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (176)
1 – 10 of 176
UBA5
Tbio
Novelty:  0.05089296
p_int:  0.998294699
p_ni:  0.001705301
Score:  0.784
Data Source:  BioPlex,STRINGDB
TBC1D25
Tbio
Novelty:  0.06756361
p_int:  0.974431357
p_ni:  0.025568643
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
Score:  0.999
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.998
Data Source:  STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
Score:  0.995
Data Source:  STRINGDB
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
Score:  0.995
Data Source:  STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.994
Data Source:  STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.994
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.992
Data Source:  STRINGDB
ATG4A
Tbio
Family:  Enzyme
Novelty:  0.04073485
Score:  0.991
Data Source:  STRINGDB
Publication Statistics
PubMed Score  443.54

PubMed score by year
PubTator Score  26.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: