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Tchem
PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Protein Summary
Description
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371953
  • ENSP00000361021
  • ENSG00000171862

Symbol
  • MMAC1
  • TEP1
  • BZS
  • DEC
  • CWS1
  • GLM2
  • MHAM
  • TEP1
  • MMAC1
  • PTEN1
  • 10q23del
  • PTENbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
disease perturbation
1
kinase
1
kinase perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5766.76   (req: < 5)
Gene RIFs: 1886   (req: <= 3)
Antibodies: 1026   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5766.76   (req: >= 5)
Gene RIFs: 1886   (req: > 3)
Antibodies: 1026   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 120
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
P6949
chemical structure image
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (118)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Deubiquitination
Disease
Diseases of signal transduction
Downstream TCR signaling
Gene Ontology Terms (137)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (883)
1 – 10 of 883
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.997
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00077082
Score: 0.996
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00082373
Score: 0.993
Data Source: STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.0026167
Score: 0.991
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.0000383
Score: 0.99
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00286014
Score: 0.988
Data Source: STRINGDB
USP7
Tchem
Family: Enzyme
Novelty: 0.00483735
Score: 0.984
Data Source: Reactome,STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00115144
Score: 0.983
Data Source: STRINGDB
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00458119
Score: 0.982
Data Source: STRINGDB
PIK3R2
Tbio
Family: Enzyme
Novelty: 0.01245674
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  5766.76

PubMed score by year
PubTator Score  4795.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNL
1-70
CAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLL
70-140
HRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGT
140-210
CNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI
210-280
PGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKT
280-350
VEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
350-403
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV